Foxm1 is a critical driver of TGF‐β‐induced EndMT in endothelial cells through Smad2/3 and binds to the Snail promoter

Endothelial‐to‐mesenchymal transition (EndMT) was first reported in heart development. Recent studies have shown that EndMT also occurs in the progression of cardiac fibrosis. Herein, we demonstrated a critical role of the Forkhead Box M1 (Foxm1) transcription factor in transforming growth factor be...

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Veröffentlicht in:	Journal of cellular physiology 2019-06, Vol.234 (6), p.9052-9064
Hauptverfasser:	Song, Shuai, Zhang, Rui, Cao, Wei, Fang, Guojian, Yu, Yi, Wan, Yi, Wang, Chuanhui, Li, Yigang, Wang, Qunshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites cardiac fibrosis Cell adhesion & migration Cell migration Cell Movement - drug effects Cells, Cultured EndMT Endothelial cells Endothelial Cells - drug effects Endothelial Cells - metabolism Epithelial-Mesenchymal Transition - drug effects Fibrosis Forkhead Box Protein M1 - genetics Forkhead Box Protein M1 - metabolism Forkhead protein Foxm1 Gene Expression Regulation Growth factors Heart Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Mesenchyme Mice, Inbred C57BL Original Original s Pathogenesis Pharmacology Promoter Regions, Genetic Signal Transduction Smad2 protein Smad2 Protein - genetics Smad2 Protein - metabolism Smad3 Protein - genetics Smad3 Protein - metabolism snail Snail Family Transcription Factors - genetics Snail Family Transcription Factors - metabolism Snail protein TGF‐β1 Transcription factors Transforming Growth Factor beta1 - pharmacology Transforming Growth Factor beta2 - pharmacology Transforming growth factor-b
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