Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35

Deficit in retromer complex function secondary to lower levels of one of its major components, the vacuolar protein sorting 35 (VPS35), has been reported in Alzheimer's disease (AD) brains. VPS35 genetic reduction results in increased Aβ levels and synaptic pathology in mouse models of the dise...

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Veröffentlicht in:	Molecular psychiatry 2020-10, Vol.25 (10), p.2630-2640
Hauptverfasser:	Li, Jian-Guo, Chiu, Jin, Praticò, Domenico
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Alzheimer Disease - genetics Alzheimer Disease - psychology Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Animals Disease Models, Animal Ethylenediaminetetraacetic acid Female Gain of Function Mutation Genetic aspects Genetic engineering Health aspects Humans Male Medical research Medicine, Experimental Memory, Short-Term Mice Mice, Transgenic Phenotype Phosphorylation Spatial Learning Target marketing tau Proteins - metabolism Vesicular Transport Proteins - genetics Vesicular Transport Proteins - metabolism
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