Immunologic Recognition of a Shared p53 Mutated Neoantigen in a Patient with Metastatic Colorectal Cancer

Adoptive cell therapy (ACT) with T cells targeting neoantigens can mediate durable responses in patients with metastatic cancer. Cell therapies targeting common shared antigens for epithelial cancers are not yet broadly available. Here, we report the identification and characterization in one patien...

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Veröffentlicht in:	Cancer immunology research 2019-04, Vol.7 (4), p.534-543
Hauptverfasser:	Lo, Winifred, Parkhurst, Maria, Robbins, Paul F, Tran, Eric, Lu, Yong-Chen, Jia, Li, Gartner, Jared J, Pasetto, Anna, Deniger, Drew, Malekzadeh, Parisa, Shelton, Thomas E, Prickett, Todd, Ray, Satyajit, Kivitz, Scott, Paria, Biman C, Kriley, Isaac, Schrump, David S, Rosenberg, Steven A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology Colorectal Neoplasms - genetics Colorectal Neoplasms - immunology Colorectal Neoplasms - pathology Female HLA-A Antigens - genetics Humans Lymphocytes, Tumor-Infiltrating - immunology Mutation Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - immunology
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