IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5

It is well established that activation of the transcription factor signal transducer and activator of transcription 1 (STAT1) is required for the interferon-γ (IFN-γ)-mediated antiviral response. Here, we found that IFN-γ receptor stimulation also activated Unc-51-like kinase 1 (ULK1), an initiator...

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Veröffentlicht in:	Science signaling 2018-11, Vol.11 (557)
Hauptverfasser:	Saleiro, Diana, Blyth, Gavin T, Kosciuczuk, Ewa M, Ozark, Patrick A, Majchrzak-Kita, Beata, Arslan, Ahmet D, Fischietti, Mariafausta, Reddy, Neha K, Horvath, Curt M, Davis, Roger J, Fish, Eleanor N, Platanias, Leonidas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral activity Autophagy Autophagy-Related Protein-1 Homolog - metabolism Beclin-1 - metabolism Catabolism Cell Line, Tumor Class III Phosphatidylinositol 3-Kinases - metabolism Cytokines - metabolism Gene Expression Profiling Genes Humans Immunity, Innate Interferon Interferon gamma Receptor Interferon-gamma - metabolism Intracellular Signaling Peptides and Proteins - metabolism Kinases MAP kinase MAP kinase kinase MAP Kinase Kinase Kinases - metabolism Mice Mitogen-Activated Protein Kinase 7 - metabolism Mitogen-Activated Protein Kinase Kinase Kinase 11 Multigene Family Phagocytosis Phosphorylation Protein Binding Protein kinase Proteins Receptors, Interferon - metabolism Recombinant Proteins - metabolism Signal Transduction Stat1 protein Stimulation Transcription activation Transcription, Genetic U937 Cells Virus Diseases - metabolism γ-Interferon
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