Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study
Background The Faroe Islands currently have the highest recorded inflammatory bowel disease (IBD) incidence in the world. Objective This study investigated environmental risk factors for IBD in the Faroese population. Methods Environmental exposure data including lifestyle risk factors and neurotoxi...
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| Veröffentlicht in: | United European gastroenterology journal 2019-08, Vol.7 (7), p.924-932 |
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| creator | Hammer, T Lophaven, S Nymand Nielsen, K Rubek Petersen, M Skaalum Munkholm, P Weihe, P Burisch, J Lynge, E |
| description | Background
The Faroe Islands currently have the highest recorded inflammatory bowel disease (IBD) incidence in the world.
Objective
This study investigated environmental risk factors for IBD in the Faroese population.
Methods
Environmental exposure data including lifestyle risk factors and neurotoxicants collected for over 30 years were retrieved from the Children's Health and the Environment in the Faroes (CHEF) cohorts including mainly mother–child pairs, with exposure data collected from pregnant mothers. For lifestyle risk factors, the incidence of IBD and ulcerative colitis (UC) was calculated as the rate ratio (RR) with 95% confidence intervals (CI) in exposed versus non-exposed persons. For neurotoxicants RR was calculated for persons with high versus low exposure.
Results
Six cohorts included 5698 persons with complete follow-up data and at least one exposure, and 37 were diagnosed with IBD. For pilot whale/blubber, the RR was 1.02 (95% CI, 0.48–2.18); RR of 1.01 for fish (95% CI, 0.35–2.91); and of the pollutants studied, a statistical significantly increased risk was found for 1,1,1,-trichloro-2,2-bis-(p-chlorophenyl) ethane (p,p'-DDT); RR 3.04 (95% CI, 1.12–8.30). RRs were 1.96 (95% CI, 1.03–3.73) for smoking and 1.10 (95% CI, 0.55–2.19) for alcohol intake.
Conclusion
The high IBD incidence is unlikely to be caused by special dietary habits or by environmental pollutants. |
| doi_str_mv | 10.1177/2050640619852244 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6683641</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_2050640619852244</sage_id><sourcerecordid>2320379152</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4841-57318f25300b31567520c329ab14ed7ef4bd6e6ab9d172d7773dfe6ace8887043</originalsourceid><addsrcrecordid>eNqFUU1P3DAUtCqqgij3npCPXFL8FdvhgFQ-FpCQkFA5W07ysmtw4sVOivbf4-3SFa1U4Yvt92bG4zcIfaPkO6VKHTNSEimIpJUuGRPiE9pblwopqNjZnoncRQcpPZK8tBYZ-AXtciqYFlTtoXjhYLRxhaNLT7izzRhiwl2I2A2dt31vc2GF6_ACHrcugU2Qcg9bvHDzRfGbtgzLydvRheEE30Oa_JglYujxuAA8szFAAnxzdoHTOLWrr-hzZ32Cg7d9Hz3MLn-eXxe3d1c35z9ui0Zkb0WpONUdKzkhNaelVCUjDWeVramAVkEn6laCtHXVUsVapRRvu3xvQGutiOD76HSju5zqHtoGhjFab5bR9fnDJlhn_u4MbmHm4ZeRUvM8xCxw9CYQw_MEaTS9Sw14bwcIUzKMM8JVRUuWoWQDbWJIKUK3fYYSs07L_JtWphy-t7cl_MkmA6oN4MV5WH0oaB4ur9jZjBBB19aLDTfZOZjHMMUhj_r_Zl4Bf3atkg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2320379152</pqid></control><display><type>article</type><title>Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><source>PubMed Central</source><creator>Hammer, T ; Lophaven, S Nymand ; Nielsen, K Rubek ; Petersen, M Skaalum ; Munkholm, P ; Weihe, P ; Burisch, J ; Lynge, E</creator><creatorcontrib>Hammer, T ; Lophaven, S Nymand ; Nielsen, K Rubek ; Petersen, M Skaalum ; Munkholm, P ; Weihe, P ; Burisch, J ; Lynge, E</creatorcontrib><description>Background
The Faroe Islands currently have the highest recorded inflammatory bowel disease (IBD) incidence in the world.
Objective
This study investigated environmental risk factors for IBD in the Faroese population.
Methods
Environmental exposure data including lifestyle risk factors and neurotoxicants collected for over 30 years were retrieved from the Children's Health and the Environment in the Faroes (CHEF) cohorts including mainly mother–child pairs, with exposure data collected from pregnant mothers. For lifestyle risk factors, the incidence of IBD and ulcerative colitis (UC) was calculated as the rate ratio (RR) with 95% confidence intervals (CI) in exposed versus non-exposed persons. For neurotoxicants RR was calculated for persons with high versus low exposure.
Results
Six cohorts included 5698 persons with complete follow-up data and at least one exposure, and 37 were diagnosed with IBD. For pilot whale/blubber, the RR was 1.02 (95% CI, 0.48–2.18); RR of 1.01 for fish (95% CI, 0.35–2.91); and of the pollutants studied, a statistical significantly increased risk was found for 1,1,1,-trichloro-2,2-bis-(p-chlorophenyl) ethane (p,p'-DDT); RR 3.04 (95% CI, 1.12–8.30). RRs were 1.96 (95% CI, 1.03–3.73) for smoking and 1.10 (95% CI, 0.55–2.19) for alcohol intake.
Conclusion
The high IBD incidence is unlikely to be caused by special dietary habits or by environmental pollutants.</description><identifier>ISSN: 2050-6406</identifier><identifier>EISSN: 2050-6414</identifier><identifier>DOI: 10.1177/2050640619852244</identifier><identifier>PMID: 31428417</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adolescent ; Adult ; Aged ; Alcohol Drinking - adverse effects ; Child ; DDT - adverse effects ; Denmark - epidemiology ; Diet - adverse effects ; Environmental Pollutants - adverse effects ; environmental risk factors ; Faroe Islands ; Female ; Humans ; Incidence ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - epidemiology ; Inflammatory Bowel Diseases - etiology ; Life Style ; Male ; Middle Aged ; Original ; Pregnancy ; Risk Factors ; Seafood - adverse effects ; Smoking - adverse effects ; Young Adult</subject><ispartof>United European gastroenterology journal, 2019-08, Vol.7 (7), p.924-932</ispartof><rights>Author(s) 2019</rights><rights>2019 The Authors. UEG Journal published by Wiley Periodicals LLC. on behalf of United European Gastroenterology</rights><rights>Author(s) 2019 2019 United European Gastroenterology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4841-57318f25300b31567520c329ab14ed7ef4bd6e6ab9d172d7773dfe6ace8887043</citedby><cites>FETCH-LOGICAL-c4841-57318f25300b31567520c329ab14ed7ef4bd6e6ab9d172d7773dfe6ace8887043</cites><orcidid>0000-0002-5242-955X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683641/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6683641/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,11562,27924,27925,45574,45575,46052,46476,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31428417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hammer, T</creatorcontrib><creatorcontrib>Lophaven, S Nymand</creatorcontrib><creatorcontrib>Nielsen, K Rubek</creatorcontrib><creatorcontrib>Petersen, M Skaalum</creatorcontrib><creatorcontrib>Munkholm, P</creatorcontrib><creatorcontrib>Weihe, P</creatorcontrib><creatorcontrib>Burisch, J</creatorcontrib><creatorcontrib>Lynge, E</creatorcontrib><title>Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study</title><title>United European gastroenterology journal</title><addtitle>United European Gastroenterol J</addtitle><description>Background
The Faroe Islands currently have the highest recorded inflammatory bowel disease (IBD) incidence in the world.
Objective
This study investigated environmental risk factors for IBD in the Faroese population.
Methods
Environmental exposure data including lifestyle risk factors and neurotoxicants collected for over 30 years were retrieved from the Children's Health and the Environment in the Faroes (CHEF) cohorts including mainly mother–child pairs, with exposure data collected from pregnant mothers. For lifestyle risk factors, the incidence of IBD and ulcerative colitis (UC) was calculated as the rate ratio (RR) with 95% confidence intervals (CI) in exposed versus non-exposed persons. For neurotoxicants RR was calculated for persons with high versus low exposure.
Results
Six cohorts included 5698 persons with complete follow-up data and at least one exposure, and 37 were diagnosed with IBD. For pilot whale/blubber, the RR was 1.02 (95% CI, 0.48–2.18); RR of 1.01 for fish (95% CI, 0.35–2.91); and of the pollutants studied, a statistical significantly increased risk was found for 1,1,1,-trichloro-2,2-bis-(p-chlorophenyl) ethane (p,p'-DDT); RR 3.04 (95% CI, 1.12–8.30). RRs were 1.96 (95% CI, 1.03–3.73) for smoking and 1.10 (95% CI, 0.55–2.19) for alcohol intake.
Conclusion
The high IBD incidence is unlikely to be caused by special dietary habits or by environmental pollutants.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Child</subject><subject>DDT - adverse effects</subject><subject>Denmark - epidemiology</subject><subject>Diet - adverse effects</subject><subject>Environmental Pollutants - adverse effects</subject><subject>environmental risk factors</subject><subject>Faroe Islands</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Inflammatory Bowel Diseases - etiology</subject><subject>Life Style</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Original</subject><subject>Pregnancy</subject><subject>Risk Factors</subject><subject>Seafood - adverse effects</subject><subject>Smoking - adverse effects</subject><subject>Young Adult</subject><issn>2050-6406</issn><issn>2050-6414</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqFUU1P3DAUtCqqgij3npCPXFL8FdvhgFQ-FpCQkFA5W07ysmtw4sVOivbf4-3SFa1U4Yvt92bG4zcIfaPkO6VKHTNSEimIpJUuGRPiE9pblwopqNjZnoncRQcpPZK8tBYZ-AXtciqYFlTtoXjhYLRxhaNLT7izzRhiwl2I2A2dt31vc2GF6_ACHrcugU2Qcg9bvHDzRfGbtgzLydvRheEE30Oa_JglYujxuAA8szFAAnxzdoHTOLWrr-hzZ32Cg7d9Hz3MLn-eXxe3d1c35z9ui0Zkb0WpONUdKzkhNaelVCUjDWeVramAVkEn6laCtHXVUsVapRRvu3xvQGutiOD76HSju5zqHtoGhjFab5bR9fnDJlhn_u4MbmHm4ZeRUvM8xCxw9CYQw_MEaTS9Sw14bwcIUzKMM8JVRUuWoWQDbWJIKUK3fYYSs07L_JtWphy-t7cl_MkmA6oN4MV5WH0oaB4ur9jZjBBB19aLDTfZOZjHMMUhj_r_Zl4Bf3atkg</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Hammer, T</creator><creator>Lophaven, S Nymand</creator><creator>Nielsen, K Rubek</creator><creator>Petersen, M Skaalum</creator><creator>Munkholm, P</creator><creator>Weihe, P</creator><creator>Burisch, J</creator><creator>Lynge, E</creator><general>SAGE Publications</general><scope>AFRWT</scope><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5242-955X</orcidid></search><sort><creationdate>201908</creationdate><title>Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study</title><author>Hammer, T ; Lophaven, S Nymand ; Nielsen, K Rubek ; Petersen, M Skaalum ; Munkholm, P ; Weihe, P ; Burisch, J ; Lynge, E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4841-57318f25300b31567520c329ab14ed7ef4bd6e6ab9d172d7773dfe6ace8887043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Child</topic><topic>DDT - adverse effects</topic><topic>Denmark - epidemiology</topic><topic>Diet - adverse effects</topic><topic>Environmental Pollutants - adverse effects</topic><topic>environmental risk factors</topic><topic>Faroe Islands</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Inflammatory Bowel Diseases - etiology</topic><topic>Life Style</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Original</topic><topic>Pregnancy</topic><topic>Risk Factors</topic><topic>Seafood - adverse effects</topic><topic>Smoking - adverse effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hammer, T</creatorcontrib><creatorcontrib>Lophaven, S Nymand</creatorcontrib><creatorcontrib>Nielsen, K Rubek</creatorcontrib><creatorcontrib>Petersen, M Skaalum</creatorcontrib><creatorcontrib>Munkholm, P</creatorcontrib><creatorcontrib>Weihe, P</creatorcontrib><creatorcontrib>Burisch, J</creatorcontrib><creatorcontrib>Lynge, E</creatorcontrib><collection>SAGE Journals</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>United European gastroenterology journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hammer, T</au><au>Lophaven, S Nymand</au><au>Nielsen, K Rubek</au><au>Petersen, M Skaalum</au><au>Munkholm, P</au><au>Weihe, P</au><au>Burisch, J</au><au>Lynge, E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study</atitle><jtitle>United European gastroenterology journal</jtitle><addtitle>United European Gastroenterol J</addtitle><date>2019-08</date><risdate>2019</risdate><volume>7</volume><issue>7</issue><spage>924</spage><epage>932</epage><pages>924-932</pages><issn>2050-6406</issn><eissn>2050-6414</eissn><abstract>Background
The Faroe Islands currently have the highest recorded inflammatory bowel disease (IBD) incidence in the world.
Objective
This study investigated environmental risk factors for IBD in the Faroese population.
Methods
Environmental exposure data including lifestyle risk factors and neurotoxicants collected for over 30 years were retrieved from the Children's Health and the Environment in the Faroes (CHEF) cohorts including mainly mother–child pairs, with exposure data collected from pregnant mothers. For lifestyle risk factors, the incidence of IBD and ulcerative colitis (UC) was calculated as the rate ratio (RR) with 95% confidence intervals (CI) in exposed versus non-exposed persons. For neurotoxicants RR was calculated for persons with high versus low exposure.
Results
Six cohorts included 5698 persons with complete follow-up data and at least one exposure, and 37 were diagnosed with IBD. For pilot whale/blubber, the RR was 1.02 (95% CI, 0.48–2.18); RR of 1.01 for fish (95% CI, 0.35–2.91); and of the pollutants studied, a statistical significantly increased risk was found for 1,1,1,-trichloro-2,2-bis-(p-chlorophenyl) ethane (p,p'-DDT); RR 3.04 (95% CI, 1.12–8.30). RRs were 1.96 (95% CI, 1.03–3.73) for smoking and 1.10 (95% CI, 0.55–2.19) for alcohol intake.
Conclusion
The high IBD incidence is unlikely to be caused by special dietary habits or by environmental pollutants.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>31428417</pmid><doi>10.1177/2050640619852244</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5242-955X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; Wiley Online Library (Open Access Collection); PubMed Central |
| subjects | Adolescent Adult Aged Alcohol Drinking - adverse effects Child DDT - adverse effects Denmark - epidemiology Diet - adverse effects Environmental Pollutants - adverse effects environmental risk factors Faroe Islands Female Humans Incidence Inflammatory bowel diseases Inflammatory Bowel Diseases - epidemiology Inflammatory Bowel Diseases - etiology Life Style Male Middle Aged Original Pregnancy Risk Factors Seafood - adverse effects Smoking - adverse effects Young Adult |
| title | Dietary risk factors for inflammatory bowel diseases in a high-risk population: Results from the Faroese IBD study |
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