Proteomic Analysis of Vocal Fold Fibroblasts Exposed to Cigarette Smoke Extract: Exploring the Pathophysiology of Reinke's Edema[S]

To explore the pathophysiology of Reinke's edema, we exposed human vocal fold fibroblasts to medium conditioned with cigarette smoke extract followed by quantitative mass spectrometry. Proteomic analyses revealed an upregulation of proteins related in oxidative stress response. Fibrillar collag...

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Veröffentlicht in:	Molecular & cellular proteomics 2019-08, Vol.18 (8), p.1511-1525
Hauptverfasser:	Gugatschka, Markus, Darnhofer, Barbara, Grossmann, Tanja, Schittmayer, Matthias, Hortobagyi, David, Kirsch, Andrijana, Karpf, Eva, Brcic, Luka, Birner-Gruenberger, Ruth, Karbiener, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Cigarette smoke Cigarette Smoking Clinical proteomics Edema - metabolism Extracellular matrix Fibroblasts - metabolism Humans Inflammation Laryngeal Diseases - metabolism Larynx Oxidative stress Protein Identification Proteomics Reinke's edema Smoke Vocal Cords - metabolism Vocal fold fibroblasts
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