Functional divergence caused by mutations in an energetic hotspot in ERK2

The most frequent extracellular signal-regulated kinase 2 (ERK2) mutation occurring in cancers is E322K (E-K). ERK2 E-K reverses a buried charge in the ERK2 common docking (CD) site, a region that binds activators, inhibitors, and substrates. Little is known about the cellular consequences associate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2019-07, Vol.116 (31), p.15514-15523
Hauptverfasser:	Taylor, Clinton A., Cormier, Kevin W., Keenan, Shannon E., Earnest, Svetlana, Stippec, Steve, Wichaidit, Chonlarat, Juang, Yu-Chi, Wang, Junmei, Shvartsman, Stanislav Y., Goldsmith, Elizabeth J., Cobb, Melanie H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified BASIC BIOLOGICAL SCIENCES Biological Sciences Crystal structure Crystallography, X-Ray Deactivation Displays Divergence Docking Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila Proteins - chemistry Drosophila Proteins - genetics Drosophila Proteins - metabolism Enzyme Activation Enzyme Stability ERK CD site Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - chemistry Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Fruit flies Humans Inactivation Inhibitors kinase Kinases Models, Molecular Mutant Proteins - metabolism Mutation Mutation - genetics Phenotypes Phosphorylation PNAS Plus Proteins stability Substrate inhibition Thermal stability
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