Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma

Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis;...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of oncology 2019, Vol.2019 (2019), p.1-16
Hauptverfasser: Yang, Qiwei, Yu, Shan, Wang, Qingyu, Chen, Gaoyang, Liu, Tao, Sun, Hongyan, Ren, Ming, Cong, Xianling, Yang, Jinghui, Li, Zhaoyan
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 16
container_issue 2019
container_start_page 1
container_title Journal of oncology
container_volume 2019
creator Yang, Qiwei
Yu, Shan
Wang, Qingyu
Chen, Gaoyang
Liu, Tao
Sun, Hongyan
Ren, Ming
Cong, Xianling
Yang, Jinghui
Li, Zhaoyan
description Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.
doi_str_mv 10.1155/2019/7630894
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6681607</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A601027800</galeid><sourcerecordid>A601027800</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-554951abc834a42193dffe97ef3c8fb5062e8513c556df9d89aeb6871a36f8373</originalsourceid><addsrcrecordid>eNqNkktv1DAURiMEoqWwY40ssUGCoXb8iL1BioYWkKZ0xGNt3TjOjKvEHuwE6D_h5-JohrawYuVr--hcX-sriqcEvyaE89MSE3VaCYqlYveKYyJktZCM4_t36qPiUUpXGAuGlXhYHFHCSkk4OS5-LV00Uw8RffpYo20CbfJBrjXGuKKUIZfQOtrWmdG2aAx5E4YwWnRxsa4Q-BYtL1ekJujs5y7alFzwqLlG55M3Y66d3yBICNDg5gafd8FvLHIercGbaGF0Br2dzAg9qlvrg4FonA8DPC4edNAn--SwnhRfz8--LN8vVpfvPizr1cJwwccF50xxAo2RlAEriaJt11lV2Y4a2TUci9JKTqjhXLSdaqUC2-RvIUBFJ2lFT4o3e-9uagbbGuvHCL3eRTdAvNYBnP77xrut3oTvWghJBJ4FLw6CGL5NNo16cMnYvgdvw5R0SalQEjOBM_r8H_QqTNHn8XTJcCWYUErdUhvorXa-C7mvmaW6FpjgspJ4dr3aUyaGlKLtbp5MsJ6Doedg6EMwMv7s7pg38J8kZODlHtg638IP9586mxnbwS1Nct6opL8BfgfHgg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2407646999</pqid></control><display><type>article</type><title>Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma</title><source>Wiley Online Library Open Access</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Yang, Qiwei ; Yu, Shan ; Wang, Qingyu ; Chen, Gaoyang ; Liu, Tao ; Sun, Hongyan ; Ren, Ming ; Cong, Xianling ; Yang, Jinghui ; Li, Zhaoyan</creator><contributor>Kanat, Ozkan</contributor><creatorcontrib>Yang, Qiwei ; Yu, Shan ; Wang, Qingyu ; Chen, Gaoyang ; Liu, Tao ; Sun, Hongyan ; Ren, Ming ; Cong, Xianling ; Yang, Jinghui ; Li, Zhaoyan ; Kanat, Ozkan</creatorcontrib><description>Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.</description><identifier>ISSN: 1687-8450</identifier><identifier>EISSN: 1687-8450</identifier><identifier>DOI: 10.1155/2019/7630894</identifier><identifier>PMID: 31428151</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adenocarcinoma ; Analysis ; Binding sites ; Gene expression ; Health aspects ; Health savings accounts ; MicroRNA ; MicroRNAs ; Pancreatic cancer ; Proteins ; RNA sequencing ; Software ; Standard deviation ; Tumors ; Wound healing</subject><ispartof>Journal of oncology, 2019, Vol.2019 (2019), p.1-16</ispartof><rights>Copyright © 2019 Jinghui Yang et al.</rights><rights>COPYRIGHT 2019 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2019 Jinghui Yang et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2019 Jinghui Yang et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-554951abc834a42193dffe97ef3c8fb5062e8513c556df9d89aeb6871a36f8373</citedby><cites>FETCH-LOGICAL-c565t-554951abc834a42193dffe97ef3c8fb5062e8513c556df9d89aeb6871a36f8373</cites><orcidid>0000-0003-3674-7491 ; 0000-0003-2566-0702 ; 0000-0002-7324-9507 ; 0000-0003-0681-2184 ; 0000-0002-6298-5357</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681607/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681607/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31428151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kanat, Ozkan</contributor><creatorcontrib>Yang, Qiwei</creatorcontrib><creatorcontrib>Yu, Shan</creatorcontrib><creatorcontrib>Wang, Qingyu</creatorcontrib><creatorcontrib>Chen, Gaoyang</creatorcontrib><creatorcontrib>Liu, Tao</creatorcontrib><creatorcontrib>Sun, Hongyan</creatorcontrib><creatorcontrib>Ren, Ming</creatorcontrib><creatorcontrib>Cong, Xianling</creatorcontrib><creatorcontrib>Yang, Jinghui</creatorcontrib><creatorcontrib>Li, Zhaoyan</creatorcontrib><title>Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma</title><title>Journal of oncology</title><addtitle>J Oncol</addtitle><description>Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.</description><subject>Adenocarcinoma</subject><subject>Analysis</subject><subject>Binding sites</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Health savings accounts</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Pancreatic cancer</subject><subject>Proteins</subject><subject>RNA sequencing</subject><subject>Software</subject><subject>Standard deviation</subject><subject>Tumors</subject><subject>Wound healing</subject><issn>1687-8450</issn><issn>1687-8450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkktv1DAURiMEoqWwY40ssUGCoXb8iL1BioYWkKZ0xGNt3TjOjKvEHuwE6D_h5-JohrawYuVr--hcX-sriqcEvyaE89MSE3VaCYqlYveKYyJktZCM4_t36qPiUUpXGAuGlXhYHFHCSkk4OS5-LV00Uw8RffpYo20CbfJBrjXGuKKUIZfQOtrWmdG2aAx5E4YwWnRxsa4Q-BYtL1ekJujs5y7alFzwqLlG55M3Y66d3yBICNDg5gafd8FvLHIercGbaGF0Br2dzAg9qlvrg4FonA8DPC4edNAn--SwnhRfz8--LN8vVpfvPizr1cJwwccF50xxAo2RlAEriaJt11lV2Y4a2TUci9JKTqjhXLSdaqUC2-RvIUBFJ2lFT4o3e-9uagbbGuvHCL3eRTdAvNYBnP77xrut3oTvWghJBJ4FLw6CGL5NNo16cMnYvgdvw5R0SalQEjOBM_r8H_QqTNHn8XTJcCWYUErdUhvorXa-C7mvmaW6FpjgspJ4dr3aUyaGlKLtbp5MsJ6Doedg6EMwMv7s7pg38J8kZODlHtg638IP9586mxnbwS1Nct6opL8BfgfHgg</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Yang, Qiwei</creator><creator>Yu, Shan</creator><creator>Wang, Qingyu</creator><creator>Chen, Gaoyang</creator><creator>Liu, Tao</creator><creator>Sun, Hongyan</creator><creator>Ren, Ming</creator><creator>Cong, Xianling</creator><creator>Yang, Jinghui</creator><creator>Li, Zhaoyan</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3674-7491</orcidid><orcidid>https://orcid.org/0000-0003-2566-0702</orcidid><orcidid>https://orcid.org/0000-0002-7324-9507</orcidid><orcidid>https://orcid.org/0000-0003-0681-2184</orcidid><orcidid>https://orcid.org/0000-0002-6298-5357</orcidid></search><sort><creationdate>2019</creationdate><title>Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma</title><author>Yang, Qiwei ; Yu, Shan ; Wang, Qingyu ; Chen, Gaoyang ; Liu, Tao ; Sun, Hongyan ; Ren, Ming ; Cong, Xianling ; Yang, Jinghui ; Li, Zhaoyan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-554951abc834a42193dffe97ef3c8fb5062e8513c556df9d89aeb6871a36f8373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Analysis</topic><topic>Binding sites</topic><topic>Gene expression</topic><topic>Health aspects</topic><topic>Health savings accounts</topic><topic>MicroRNA</topic><topic>MicroRNAs</topic><topic>Pancreatic cancer</topic><topic>Proteins</topic><topic>RNA sequencing</topic><topic>Software</topic><topic>Standard deviation</topic><topic>Tumors</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Qiwei</creatorcontrib><creatorcontrib>Yu, Shan</creatorcontrib><creatorcontrib>Wang, Qingyu</creatorcontrib><creatorcontrib>Chen, Gaoyang</creatorcontrib><creatorcontrib>Liu, Tao</creatorcontrib><creatorcontrib>Sun, Hongyan</creatorcontrib><creatorcontrib>Ren, Ming</creatorcontrib><creatorcontrib>Cong, Xianling</creatorcontrib><creatorcontrib>Yang, Jinghui</creatorcontrib><creatorcontrib>Li, Zhaoyan</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health &amp; Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Qiwei</au><au>Yu, Shan</au><au>Wang, Qingyu</au><au>Chen, Gaoyang</au><au>Liu, Tao</au><au>Sun, Hongyan</au><au>Ren, Ming</au><au>Cong, Xianling</au><au>Yang, Jinghui</au><au>Li, Zhaoyan</au><au>Kanat, Ozkan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma</atitle><jtitle>Journal of oncology</jtitle><addtitle>J Oncol</addtitle><date>2019</date><risdate>2019</risdate><volume>2019</volume><issue>2019</issue><spage>1</spage><epage>16</epage><pages>1-16</pages><issn>1687-8450</issn><eissn>1687-8450</eissn><abstract>Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31428151</pmid><doi>10.1155/2019/7630894</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-3674-7491</orcidid><orcidid>https://orcid.org/0000-0003-2566-0702</orcidid><orcidid>https://orcid.org/0000-0002-7324-9507</orcidid><orcidid>https://orcid.org/0000-0003-0681-2184</orcidid><orcidid>https://orcid.org/0000-0002-6298-5357</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1687-8450
ispartof Journal of oncology, 2019, Vol.2019 (2019), p.1-16
issn 1687-8450
1687-8450
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6681607
source Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access
subjects Adenocarcinoma
Analysis
Binding sites
Gene expression
Health aspects
Health savings accounts
MicroRNA
MicroRNAs
Pancreatic cancer
Proteins
RNA sequencing
Software
Standard deviation
Tumors
Wound healing
title Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T19%3A33%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Circular%20RNA%20hsa_circRNA_0007334%20is%20Predicted%20to%20Promote%20MMP7%20and%20COL1A1%20Expression%20by%20Functioning%20as%20a%20miRNA%20Sponge%20in%20Pancreatic%20Ductal%20Adenocarcinoma&rft.jtitle=Journal%20of%20oncology&rft.au=Yang,%20Qiwei&rft.date=2019&rft.volume=2019&rft.issue=2019&rft.spage=1&rft.epage=16&rft.pages=1-16&rft.issn=1687-8450&rft.eissn=1687-8450&rft_id=info:doi/10.1155/2019/7630894&rft_dat=%3Cgale_pubme%3EA601027800%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2407646999&rft_id=info:pmid/31428151&rft_galeid=A601027800&rfr_iscdi=true