Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma
Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis;...
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description | Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1. |
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Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.</description><identifier>ISSN: 1687-8450</identifier><identifier>EISSN: 1687-8450</identifier><identifier>DOI: 10.1155/2019/7630894</identifier><identifier>PMID: 31428151</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adenocarcinoma ; Analysis ; Binding sites ; Gene expression ; Health aspects ; Health savings accounts ; MicroRNA ; MicroRNAs ; Pancreatic cancer ; Proteins ; RNA sequencing ; Software ; Standard deviation ; Tumors ; Wound healing</subject><ispartof>Journal of oncology, 2019, Vol.2019 (2019), p.1-16</ispartof><rights>Copyright © 2019 Jinghui Yang et al.</rights><rights>COPYRIGHT 2019 John Wiley & Sons, Inc.</rights><rights>Copyright © 2019 Jinghui Yang et al. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2019 Jinghui Yang et al. 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-554951abc834a42193dffe97ef3c8fb5062e8513c556df9d89aeb6871a36f8373</citedby><cites>FETCH-LOGICAL-c565t-554951abc834a42193dffe97ef3c8fb5062e8513c556df9d89aeb6871a36f8373</cites><orcidid>0000-0003-3674-7491 ; 0000-0003-2566-0702 ; 0000-0002-7324-9507 ; 0000-0003-0681-2184 ; 0000-0002-6298-5357</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681607/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681607/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31428151$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Kanat, Ozkan</contributor><creatorcontrib>Yang, Qiwei</creatorcontrib><creatorcontrib>Yu, Shan</creatorcontrib><creatorcontrib>Wang, Qingyu</creatorcontrib><creatorcontrib>Chen, Gaoyang</creatorcontrib><creatorcontrib>Liu, Tao</creatorcontrib><creatorcontrib>Sun, Hongyan</creatorcontrib><creatorcontrib>Ren, Ming</creatorcontrib><creatorcontrib>Cong, Xianling</creatorcontrib><creatorcontrib>Yang, Jinghui</creatorcontrib><creatorcontrib>Li, Zhaoyan</creatorcontrib><title>Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma</title><title>Journal of oncology</title><addtitle>J Oncol</addtitle><description>Pancreatic cancer remains one of the leading causes of cancer-related deaths worldwide. Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.</description><subject>Adenocarcinoma</subject><subject>Analysis</subject><subject>Binding sites</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Health savings accounts</subject><subject>MicroRNA</subject><subject>MicroRNAs</subject><subject>Pancreatic cancer</subject><subject>Proteins</subject><subject>RNA sequencing</subject><subject>Software</subject><subject>Standard deviation</subject><subject>Tumors</subject><subject>Wound healing</subject><issn>1687-8450</issn><issn>1687-8450</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkktv1DAURiMEoqWwY40ssUGCoXb8iL1BioYWkKZ0xGNt3TjOjKvEHuwE6D_h5-JohrawYuVr--hcX-sriqcEvyaE89MSE3VaCYqlYveKYyJktZCM4_t36qPiUUpXGAuGlXhYHFHCSkk4OS5-LV00Uw8RffpYo20CbfJBrjXGuKKUIZfQOtrWmdG2aAx5E4YwWnRxsa4Q-BYtL1ekJujs5y7alFzwqLlG55M3Y66d3yBICNDg5gafd8FvLHIercGbaGF0Br2dzAg9qlvrg4FonA8DPC4edNAn--SwnhRfz8--LN8vVpfvPizr1cJwwccF50xxAo2RlAEriaJt11lV2Y4a2TUci9JKTqjhXLSdaqUC2-RvIUBFJ2lFT4o3e-9uagbbGuvHCL3eRTdAvNYBnP77xrut3oTvWghJBJ4FLw6CGL5NNo16cMnYvgdvw5R0SalQEjOBM_r8H_QqTNHn8XTJcCWYUErdUhvorXa-C7mvmaW6FpjgspJ4dr3aUyaGlKLtbp5MsJ6Doedg6EMwMv7s7pg38J8kZODlHtg638IP9586mxnbwS1Nct6opL8BfgfHgg</recordid><startdate>2019</startdate><enddate>2019</enddate><creator>Yang, Qiwei</creator><creator>Yu, Shan</creator><creator>Wang, Qingyu</creator><creator>Chen, Gaoyang</creator><creator>Liu, Tao</creator><creator>Sun, Hongyan</creator><creator>Ren, Ming</creator><creator>Cong, Xianling</creator><creator>Yang, Jinghui</creator><creator>Li, Zhaoyan</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3674-7491</orcidid><orcidid>https://orcid.org/0000-0003-2566-0702</orcidid><orcidid>https://orcid.org/0000-0002-7324-9507</orcidid><orcidid>https://orcid.org/0000-0003-0681-2184</orcidid><orcidid>https://orcid.org/0000-0002-6298-5357</orcidid></search><sort><creationdate>2019</creationdate><title>Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma</title><author>Yang, Qiwei ; 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Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in the physiological and pathological processes of tumorigenesis; however, their biogenesis in PDAC remains unclear. In this study, the expression profiles of circRNAs from 10 PDAC tissues and their paired adjacent nontumor tissues were analyzed through RNA sequencing analysis. An enrichment analysis was employed to predict the functions of the differentially expressed circRNAs. Sequence alignment information and mRNA microarray projects were used to predict the RNA regulatory network. The knockdown of circRNAs by small interfering RNAs followed by wound healing and western blot assays was used to confirm their functions in a PDAC cell line. A total of 278 circRNAs were identified as differentially expressed in PDAC tissue. Of these, we found that hsa_circRNA_0007334 was significantly upregulated and may serve as a competing endogenous RNA to regulate matrix metallopeptidase 7 (MMP7) and collagen type I alpha 1 chain (COL1A1) by the competitive adsorption of hsa-miR-144-3p and hsa-miR-577 to enhance the expression and functions of MMP7 and COL1A1 in PDAC. In vitro experiments confirmed these results. The present study is the first to propose two regulatory pathways in PDAC: hsa_circRNA_0007334–hsa-miR-144-3p–MMP7 and hsa_circRNA_0007334–hsa-miR-577–COL1A1.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>31428151</pmid><doi>10.1155/2019/7630894</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-3674-7491</orcidid><orcidid>https://orcid.org/0000-0003-2566-0702</orcidid><orcidid>https://orcid.org/0000-0002-7324-9507</orcidid><orcidid>https://orcid.org/0000-0003-0681-2184</orcidid><orcidid>https://orcid.org/0000-0002-6298-5357</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adenocarcinoma Analysis Binding sites Gene expression Health aspects Health savings accounts MicroRNA MicroRNAs Pancreatic cancer Proteins RNA sequencing Software Standard deviation Tumors Wound healing |
title | Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma |
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