NAD+‐Dependent Enzymatic Route for the Epimerization of Hydroxysteroids

Epimerization of cholic and chenodeoxycholic acid (CA and CDCA, respectively) is a notable conversion for the production of ursodeoxycholic acid (UDCA). Two enantiocomplementary hydroxysteroid dehydrogenases (7α‐ and 7β‐HSDHs) can carry out this transformation fully selectively by specific oxidation...

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Veröffentlicht in:	ChemSusChem 2019-07, Vol.12 (13), p.3192-3203
Hauptverfasser:	Tonin, Fabio, Otten, Linda G., Arends, Isabel W. C. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Biotransformation carboxylic acids Catalysis Chenodeoxycholic Acid - metabolism Cholic Acid - metabolism Clostridium - enzymology cofactors enzymes Hydrogen-Ion Concentration Hydroxysteroid Dehydrogenases - metabolism Hydroxysteroids Kinetics Lactobacillus - enzymology NAD - metabolism Nicotinamide adenine dinucleotide Oxidation Oxidation-Reduction Stenotrophomonas maltophilia - enzymology steroids Substrates Temperature
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