IL-36γ Promotes Killing of Mycobacterium tuberculosis by Macrophages via WNT5A-Induced Noncanonical WNT Signaling

, which primarily infects mononuclear phagocytes, remains the leading bacterial cause of enormous morbidity and mortality because of bacterial infections in humans throughout the world. The IL-1 family of cytokines is critical for host resistance to As a newly discovered subgroup of the IL-1 family,...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-08, Vol.203 (4), p.922-935
Hauptverfasser:	Gao, Yuchi, Wen, Qian, Hu, Shengfeng, Zhou, Xinying, Xiong, Wenjing, Du, Xialin, Zhang, Lijie, Fu, Yuling, Yang, Jiahui, Zhou, Chaoying, Zhang, Zelin, Li, Yanfen, Liu, Honglin, Huang, Yulan, Ma, Li
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy - immunology Humans Infectious Disease and Host Response Interleukin-1 - immunology Interleukin-1 - metabolism Macrophages - immunology Macrophages - metabolism Macrophages - microbiology Mycobacterium tuberculosis - immunology Signal Transduction - immunology Tuberculosis, Pulmonary - immunology Tuberculosis, Pulmonary - metabolism Wnt-5a Protein - immunology Wnt-5a Protein - metabolism
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