Cholesterol Crystals Induce Coagulation Activation through Complement-Dependent Expression of Monocytic Tissue Factor

Cholesterol crystals (CC) are strong activators of complement and could potentially be involved in thromboinflammation through complement-coagulation cross-talk. To explore the coagulation-inducing potential of CC, we performed studies in lepirudin-based human whole blood and plasma models. In addit...

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Veröffentlicht in:	The Journal of immunology (1950) 2019-08, Vol.203 (4), p.853-863
Hauptverfasser:	Gravastrand, Caroline S, Steinkjer, Bjørg, Halvorsen, Bente, Landsem, Anne, Skjelland, Mona, Jacobsen, Eva Astrid, Woodruff, Trent M, Lambris, John D, Mollnes, Tom E, Brekke, Ole-Lars, Espevik, Terje, Rokstad, Anne Mari A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antikoagulasjonsbehandling / Anticoagulation Basale medisinske, odontologiske og veterinærmedisinske fag: 710 Basic medical, dental and veterinary sciences: 710 Blood Coagulation - immunology Carotid Artery Diseases - immunology Carotid Artery Diseases - metabolism Cholesterol - immunology Clinical and Human Immunology Complement Activation - immunology Humans Kolesterolkrystaller / Cholesterol crystals Komplement / Complement Medical immunology: 716 Medisinsk immunologi: 716 Medisinske fag: 700 Midical sciences: 700 Monocytes - immunology Monocytes - metabolism Receptor, Anaphylatoxin C5a - metabolism Thromboplastin - biosynthesis Thromboplastin - immunology Thrombosis - immunology Thrombosis - metabolism Tromboinflammasjon / Tromboinflammation VDP
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