HDAC3 Deficiency Promotes Liver Cancer through a Defect in H3K9ac/H3K9me3 Transition

DNA damage triggers diverse cancers, particularly hepatocellular carcinoma (HCC), but the intrinsic link between DNA damage and tumorigenesis remains unclear. Because of its role as an epigenetic and transcriptional regulator, histone deacetylase 3 (HDAC3) is essential for DNA damage control and is...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-07, Vol.79 (14), p.3676-3688
Hauptverfasser:	Ji, Hongjie, Zhou, Yongjie, Zhuang, Xiang, Zhu, Yongjie, Wu, Zhenru, Lu, Yannrong, Li, Shengfu, Zeng, Yong, Lu, Qing R, Huo, Yanying, Shi, Yujun, Bu, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - enzymology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Cellular Reprogramming - physiology DNA Damage DNA Repair Histone Deacetylases - deficiency Histone Deacetylases - genetics Histone Deacetylases - metabolism Histones - genetics Histones - metabolism Humans Liver Neoplasms - enzymology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms, Experimental - enzymology Liver Neoplasms, Experimental - genetics Liver Neoplasms, Experimental - metabolism Mice Mice, Knockout Mice, Transgenic Transcription, Genetic Transcriptome
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