Emerging diverse roles of telocytes
Since the first description of 'interstitial cells of Cajal' in the mammalian gut in 1911, scientists have found structurally similar cells, now termed telocytes, in numerous tissues throughout the body. These cells have recently sparked renewed interest, facilitated through the developmen...
Gespeichert in:
Veröffentlicht in: | Development (Cambridge) 2019-07, Vol.146 (14) |
---|---|
Hauptverfasser: | , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | |
---|---|
container_issue | 14 |
container_start_page | |
container_title | Development (Cambridge) |
container_volume | 146 |
creator | Kondo, Ayano Kaestner, Klaus H |
description | Since the first description of 'interstitial cells of Cajal' in the mammalian gut in 1911, scientists have found structurally similar cells, now termed telocytes, in numerous tissues throughout the body. These cells have recently sparked renewed interest, facilitated through the development of a molecular handle to genetically manipulate their function in tissue homeostasis and disease. In this Primer, we discuss the discovery of telocytes, their physical properties, distribution and function, focusing on recent developments in the functional analysis of Foxl1-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of studying telocytes as a distinct cell type. |
doi_str_mv | 10.1242/dev.175018 |
format | Article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6679369</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2259356082</sourcerecordid><originalsourceid>FETCH-LOGICAL-c444t-46632b3cddacf4efce2fa22b345c25c439d401ec3db14ef1bc7e12715107246f3</originalsourceid><addsrcrecordid>eNpVkE1Lw0AQhhdRbK1e_AES8CJC6s5-di-ClPoBBS96XpLNpEaSbN1NA_33RlqLngbmfXhneAi5BDoFJthdgf0UtKQwOyJjEFqnBpg5JmNqJE3BGBiRsxg_KaVcaX1KRhw4wIzKMbleNBhWVbtKiqrHEDEJvsaY-DLpsPZu22E8JydlVke82M8JeX9cvM2f0-Xr08v8YZk6IUSXCqU4y7krisyVAkuHrMzYsBHSMekEN4WggI4XOQwx5E4jMA0SqGZClXxC7ne9603eYOGw7UJW23Womixsrc8q-z9pqw-78r1VShuuzFBwsy8I_muDsbNNFR3Wddai30TLmDRcKjpjA3q7Q13wMQYsD2eA2h-rdrBqd1YH-OrvYwf0VyP_BkDPcu8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2259356082</pqid></control><display><type>article</type><title>Emerging diverse roles of telocytes</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>Kondo, Ayano ; Kaestner, Klaus H</creator><creatorcontrib>Kondo, Ayano ; Kaestner, Klaus H</creatorcontrib><description>Since the first description of 'interstitial cells of Cajal' in the mammalian gut in 1911, scientists have found structurally similar cells, now termed telocytes, in numerous tissues throughout the body. These cells have recently sparked renewed interest, facilitated through the development of a molecular handle to genetically manipulate their function in tissue homeostasis and disease. In this Primer, we discuss the discovery of telocytes, their physical properties, distribution and function, focusing on recent developments in the functional analysis of Foxl1-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of studying telocytes as a distinct cell type.</description><identifier>ISSN: 0950-1991</identifier><identifier>EISSN: 1477-9129</identifier><identifier>DOI: 10.1242/dev.175018</identifier><identifier>PMID: 31311805</identifier><language>eng</language><publisher>England: The Company of Biologists Ltd</publisher><subject>Primer</subject><ispartof>Development (Cambridge), 2019-07, Vol.146 (14)</ispartof><rights>2019. Published by The Company of Biologists Ltd.</rights><rights>2019. Published by The Company of Biologists Ltd 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-46632b3cddacf4efce2fa22b345c25c439d401ec3db14ef1bc7e12715107246f3</citedby><cites>FETCH-LOGICAL-c444t-46632b3cddacf4efce2fa22b345c25c439d401ec3db14ef1bc7e12715107246f3</cites><orcidid>0000-0002-1228-021X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31311805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondo, Ayano</creatorcontrib><creatorcontrib>Kaestner, Klaus H</creatorcontrib><title>Emerging diverse roles of telocytes</title><title>Development (Cambridge)</title><addtitle>Development</addtitle><description>Since the first description of 'interstitial cells of Cajal' in the mammalian gut in 1911, scientists have found structurally similar cells, now termed telocytes, in numerous tissues throughout the body. These cells have recently sparked renewed interest, facilitated through the development of a molecular handle to genetically manipulate their function in tissue homeostasis and disease. In this Primer, we discuss the discovery of telocytes, their physical properties, distribution and function, focusing on recent developments in the functional analysis of Foxl1-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of studying telocytes as a distinct cell type.</description><subject>Primer</subject><issn>0950-1991</issn><issn>1477-9129</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpVkE1Lw0AQhhdRbK1e_AES8CJC6s5-di-ClPoBBS96XpLNpEaSbN1NA_33RlqLngbmfXhneAi5BDoFJthdgf0UtKQwOyJjEFqnBpg5JmNqJE3BGBiRsxg_KaVcaX1KRhw4wIzKMbleNBhWVbtKiqrHEDEJvsaY-DLpsPZu22E8JydlVke82M8JeX9cvM2f0-Xr08v8YZk6IUSXCqU4y7krisyVAkuHrMzYsBHSMekEN4WggI4XOQwx5E4jMA0SqGZClXxC7ne9603eYOGw7UJW23Womixsrc8q-z9pqw-78r1VShuuzFBwsy8I_muDsbNNFR3Wddai30TLmDRcKjpjA3q7Q13wMQYsD2eA2h-rdrBqd1YH-OrvYwf0VyP_BkDPcu8</recordid><startdate>20190715</startdate><enddate>20190715</enddate><creator>Kondo, Ayano</creator><creator>Kaestner, Klaus H</creator><general>The Company of Biologists Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1228-021X</orcidid></search><sort><creationdate>20190715</creationdate><title>Emerging diverse roles of telocytes</title><author>Kondo, Ayano ; Kaestner, Klaus H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-46632b3cddacf4efce2fa22b345c25c439d401ec3db14ef1bc7e12715107246f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Primer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, Ayano</creatorcontrib><creatorcontrib>Kaestner, Klaus H</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Development (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, Ayano</au><au>Kaestner, Klaus H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Emerging diverse roles of telocytes</atitle><jtitle>Development (Cambridge)</jtitle><addtitle>Development</addtitle><date>2019-07-15</date><risdate>2019</risdate><volume>146</volume><issue>14</issue><issn>0950-1991</issn><eissn>1477-9129</eissn><abstract>Since the first description of 'interstitial cells of Cajal' in the mammalian gut in 1911, scientists have found structurally similar cells, now termed telocytes, in numerous tissues throughout the body. These cells have recently sparked renewed interest, facilitated through the development of a molecular handle to genetically manipulate their function in tissue homeostasis and disease. In this Primer, we discuss the discovery of telocytes, their physical properties, distribution and function, focusing on recent developments in the functional analysis of Foxl1-positive telocytes in the intestinal stem cell niche, and, finally, the current challenges of studying telocytes as a distinct cell type.</abstract><cop>England</cop><pub>The Company of Biologists Ltd</pub><pmid>31311805</pmid><doi>10.1242/dev.175018</doi><orcidid>https://orcid.org/0000-0002-1228-021X</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0950-1991 |
ispartof | Development (Cambridge), 2019-07, Vol.146 (14) |
issn | 0950-1991 1477-9129 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6679369 |
source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
subjects | Primer |
title | Emerging diverse roles of telocytes |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T00%3A03%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Emerging%20diverse%20roles%20of%20telocytes&rft.jtitle=Development%20(Cambridge)&rft.au=Kondo,%20Ayano&rft.date=2019-07-15&rft.volume=146&rft.issue=14&rft.issn=0950-1991&rft.eissn=1477-9129&rft_id=info:doi/10.1242/dev.175018&rft_dat=%3Cproquest_pubme%3E2259356082%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2259356082&rft_id=info:pmid/31311805&rfr_iscdi=true |