Platelets Are Critical Key Players in Sepsis
Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of ma...
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| Veröffentlicht in: | International journal of molecular sciences 2019-07, Vol.20 (14), p.3494 |
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| creator | Vardon-Bounes, Fanny Ruiz, Stéphanie Gratacap, Marie-Pierre Garcia, Cédric Payrastre, Bernard Minville, Vincent |
| description | Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet-pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed. |
| doi_str_mv | 10.3390/ijms20143494 |
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Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet-pathogens interactions. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Bacterial Toxins - toxicity Blood platelets Blood Platelets - immunology Blood Platelets - pathology Cardiology and cardiovascular system Collagen Endothelium, Vascular - immunology Endothelium, Vascular - pathology Fibrinogen Fibronectin Glycoproteins Human health and pathology Humans Intensive care Laboratories Laminin Life Sciences Mortality Neutrophils Pathogens Review Sepsis Sepsis - blood Sepsis - complications Septic shock Thrombocytopenia Thrombocytopenia - blood Thrombocytopenia - etiology Thrombosis Thrombospondin Von Willebrand factor |
| title | Platelets Are Critical Key Players in Sepsis |
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