Design of novel JAK3 Inhibitors towards Rheumatoid Arthritis using molecular docking analysis

Multiple cytokines play a pivotal role in the pathogenesis of Rheumatoid Arthritis by inducing intracellular signaling and it is known that the members of the Janus kinase (JAK) family are essential for such signal transduction. Janus kinase 3 is a tyrosine kinase that belongs to the Janus family of...

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Veröffentlicht in:	Bioinformation 2019, Vol.15 (2), p.68-78
Hauptverfasser:	Jain, Divya, Udhwani, Trishang, Sharma, Shreshtha, Gandhe, Aishwarya, Reddy, Palugulla Bhaskar, Nayarisseri, Anuraj, Singh, Sanjeev Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Arthritis Cytokines Drug delivery Drugs Inhibitors Intracellular signalling Janus kinase Janus kinase 3 Kinases Molecular docking Molecular structure Pathogenesis Protein-tyrosine kinase Proteins Rheumatoid arthritis Signal transduction Tyrosine
Online-Zugang:	Volltext
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