A genome-wide association study identifies genetic loci associated with specific lobar brain volumes

Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific l...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Communications biology 2019-08, Vol.2 (1), p.285, Article 285
Hauptverfasser:	van der Lee, Sven J., Knol, Maria J., Chauhan, Ganesh, Satizabal, Claudia L., Smith, Albert Vernon, Hofer, Edith, Bis, Joshua C., Hibar, Derrek P., Hilal, Saima, van den Akker, Erik B., Arfanakis, Konstantinos, Bernard, Manon, Yanek, Lisa R., Amin, Najaf, Crivello, Fabrice, Cheung, Josh W., Harris, Tamara B., Saba, Yasaman, Lopez, Oscar L., Li, Shuo, van der Grond, Jeroen, Yu, Lei, Paus, Tomas, Roshchupkin, Gennady V., Amouyel, Philippe, Jahanshad, Neda, Taylor, Kent D., Yang, Qiong, Mathias, Rasika A., Boehringer, Stefan, Mazoyer, Bernard, Rice, Ken, Cheng, Ching Yu, Maillard, Pauline, van Heemst, Diana, Wong, Tien Yin, Niessen, Wiro J., Beiser, Alexa S., Beekman, Marian, Zhao, Wanting, Nyquist, Paul A., Chen, Christopher, Launer, Lenore J., Psaty, Bruce M., Ikram, M. Kamran, Vernooij, Meike W., Schmidt, Helena, Pausova, Zdenka, Becker, Diane M., De Jager, Philip L., Thompson, Paul M., van Duijn, Cornelia M., Bennett, David A., Slagboom, P. Eline, Schmidt, Reinhold, Longstreth, W. T., Ikram, M. Arfan, Seshadri, Sudha, Debette, Stéphanie, Gudnason, Vilmundur, Adams, Hieab H. H., DeCarli, Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	45/43 59/57 631/208/205/2138 692/53 692/617 Biology Biomedical and Life Sciences Chromosome 6 Frontal Lobe - diagnostic imaging Frontal Lobe - growth & development Gene Expression Regulation, Developmental Gene loci Genetic Loci Genetic Variation Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genotype Heredity Hippocampus Humans Life Sciences Magnetic Resonance Imaging Mental disorders Neurobiology Neurons and Cognition Occipital lobe Occipital Lobe - diagnostic imaging Occipital Lobe - growth & development Organ Size - genetics Parietal lobe Parietal Lobe - diagnostic imaging Parietal Lobe - growth & development Phenotype Populations and Evolution Regulatory sequences Temporal lobe Temporal Lobe - drug effects Temporal Lobe - growth & development United Kingdom
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!