IRF1 inhibits antitumor immunity through the upregulation of PD-L1 in the tumor cell: Tumor promoting activity of IRF1

Multiple studies have associated the transcription factor IRF1 with tumor suppressive activities. Here we report an opposite tumor cell–intrinsic function of IRF1 in promoting tumor growth. IRF1-deficient tumor cells showed reduced tumor growth in MC38 and CT26 colon carcinoma and B16 melanoma mouse...

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Veröffentlicht in:	Cancer immunology research 2019-06
Hauptverfasser:	Shao, Lulu, Hou, Weizhou, Scharping, Nicole E., Vendetti, Frank P., Srivastava, Rashmi, Roy, Chandra Nath, Menk, Ashley V., Wang, Yiyang, Chauvin, Joe-Marc, Karukonda, Pooja, Thorne, Stephen H., Hornung, Veit, Zarour, Hassane M., Bakkenist, Christopher J., Delgoffe, Greg M., Sarkar, Saumendra N.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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