Interleukin‐6 production mediated by the IRE1‐XBP1 pathway confers radioresistance in human papillomavirus‐negative oropharyngeal carcinoma

Endoplasmic reticulum stress (ERS) plays a key role in the pathogenesis and development of tumors and protects tumor cells from radiation damage and drug‐induced stress. We previously demonstrated that EGFR confers radioresistance in human papillomavirus (HPV)‐negative human oropharyngeal carcinoma...

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Veröffentlicht in:	Cancer science 2019-08, Vol.110 (8), p.2471-2484
Hauptverfasser:	Lyu, Xintong, Zhang, Miao, Li, Guangqi, Cai, Yiru, Li, Guang, Qiao, Qiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor DNA Breaks, Double-Stranded DNA-Binding Proteins - metabolism Endoplasmic Reticulum Stress - physiology Endoribonucleases - metabolism Humans Interleukin-6 - metabolism interleukin‐6 IRE1 NF-kappa B - metabolism Original oropharyngeal carcinoma Oropharyngeal Neoplasms - metabolism Oropharyngeal Neoplasms - pathology Papillomaviridae - pathogenicity Papillomavirus Infections - metabolism Papillomavirus Infections - pathology Protein-Serine-Threonine Kinases - metabolism Radiation Tolerance - physiology radiotherapy Signal Transduction - physiology Transcription Factors - metabolism X-Box Binding Protein 1 - metabolism XBP1
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