An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice

The adenosine analogue galidesivir (BCX4430), a broad-spectrum RNA virus inhibitor, has entered a phase 1 clinical safety and pharmacokinetics study in healthy subjects and is under clinical development for treatment of Ebola and yellow fever virus infections. Moreover, galidesivir also inhibits the...

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Veröffentlicht in:	Journal of virology 2019-08, Vol.93 (16), p.e00367-19
Hauptverfasser:	Eyer, Ludek, Nougairède, Antoine, Uhlířová, Marie, Driouich, Jean-Sélim, Zouharová, Darina, Valdés, James J, Haviernik, Jan, Gould, Ernest A, De Clercq, Erik, de Lamballerie, Xavier, Ruzek, Daniel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - chemistry Adenine - pharmacology Adenosine - analogs & derivatives Alleles Amino Acid Substitution Animals Antiviral Agents - chemistry Antiviral Agents - pharmacology Cell Line Disease Models, Animal Drug Resistance, Microbial Drug Resistance, Viral Encephalitis Viruses, Tick-Borne - drug effects Encephalitis Viruses, Tick-Borne - physiology Encephalitis, Tick-Borne - drug therapy Encephalitis, Tick-Borne - virology Genotype Human health and pathology Infectious diseases Life Sciences Mice Microbiology and Parasitology Mutation Pyrrolidines - chemistry Pyrrolidines - pharmacology Spotlight Vaccines and Antiviral Agents Viral Nonstructural Proteins - genetics
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