Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms
Alcoholism arises from combined effects of multiple biological factors including genetic and non-genetic causes with gene/environmental interaction. Intensive research and advanced genetic technology has generated a long list of genes and biomarkers involved in alcoholism neuropathology. These marke...
Gespeichert in:
| Veröffentlicht in: | Gene 2015-04, Vol.560 (2), p.184-194 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 194 |
|---|---|
| container_issue | 2 |
| container_start_page | 184 |
| container_title | Gene |
| container_volume | 560 |
| creator | Manzardo, Ann M. McGuire, Austen Butler, Merlin G. |
| description | Alcoholism arises from combined effects of multiple biological factors including genetic and non-genetic causes with gene/environmental interaction. Intensive research and advanced genetic technology has generated a long list of genes and biomarkers involved in alcoholism neuropathology. These markers reflect complex overlapping and competing effects of possibly hundreds of genes which impact brain structure, function, biochemical alcohol processing, sensitivity and risk for dependence.
We compiled a tabular list of clinically relevant genetic biomarkers for alcoholism targeting expression disturbances in the human brain through an extensive search of keywords related to alcoholism, alcohol abuse, and genetics from peer reviewed medical research articles and related nationally sponsored websites. Gene symbols were then placed on high resolution human chromosome ideograms with gene descriptions in tabular form.
We identified 337 clinically relevant genetic biomarkers and candidate genes for alcoholism and alcohol-responsiveness from human brain research. Genetic biomarkers included neurotransmitter pathways associated with brain reward processes for dopaminergic (e.g., DRD2, MAOA, and COMT), serotoninergic (e.g., HTR3A, HTR1B, HTR3B, and SLC6A4), GABAergic (e.g., GABRA1, GABRA2, and GABRG1), glutaminergic (GAD1, GRIK3, and GRIN2C) and opioid (e.g., OPRM1, OPRD1, and OPRK1) pathways which presumably impact reinforcing properties of alcohol. Gene level disturbances in cellular and molecular networks impacted by alcohol and alcoholism pathology include transketolase (TKT), transferrin (TF), and myelin (e.g., MBP, MOBP, and MOG).
High resolution chromosome ideograms provide investigators, physicians, geneticists and counselors a convenient visual image of the distribution of alcoholism genetic biomarkers from brain research with alphabetical listing of genes in tabular form allowing comparison between alcoholism-related phenotypes, and clinically-relevant alcoholism gene(s) at the chromosome band level to guide research, diagnosis, and treatment. Chromosome ideograms may facilitate gene-based personalized counseling of alcohol dependent individuals and their families.
[Display omitted]
•The work provides a current review of clinically relevant genetic biomarkers for alcoholism.•Provides a convenient visual image of the distribution of genes for alcoholism biomarkers at the chromosome band level•Provides an alphabetical listing of genes in tabular form for compa |
| doi_str_mv | 10.1016/j.gene.2015.01.064 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6675570</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378111915001213</els_id><sourcerecordid>1660444108</sourcerecordid><originalsourceid>FETCH-LOGICAL-c521t-9fd1b85f4f34117138fed8b09736efe3df63cb0b90ee5f34edfd4ded97dbe8143</originalsourceid><addsrcrecordid>eNqFkt-L1DAQx4so3t7pP-CD9NGX1kybXwURZFFPOPBFn0OaTLdZ02ZNuiv35L9u6p6HvnhhIDD5zJeZybcoXgCpgQB_va93OGPdEGA1gZpw-qjYgBRdRUgrHxcb0gpZAUB3UVymtCf5MNY8LS4axhmjHDbFz613szPa-9syoseTnpdylV2cKXsXJh2_YUzlEMNULiOWfdRuLnNob8IYvEtT-cMtY64-REw4L3pxYS5zjG63plPwx98pM2aRkMKEpbMYdlFP6VnxZNA-4fO7-6r4-uH9l-11dfP546ftu5vKsAaWqhss9JINdGgpgIBWDmhlTzrRchywtQNvTU_6jiCyzKAdLLVoO2F7lEDbq-LtWfdw7Ce0JvcZtVeH6PKEtypop_59md2oduGkOBeMCZIFXt0JxPD9iGlRk0sGvdczhmNSTV4uUAGifRAF0QguiRTNwyjnhFIKRGa0OaMmhpQiDvfNA1GrH9RerR-nVj8oAir7IRe9_Hvs-5I_BsjAmzOAefknh1El43A2aF1Esygb3P_0fwGw5st5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1660444108</pqid></control><display><type>article</type><title>Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Manzardo, Ann M. ; McGuire, Austen ; Butler, Merlin G.</creator><creatorcontrib>Manzardo, Ann M. ; McGuire, Austen ; Butler, Merlin G.</creatorcontrib><description>Alcoholism arises from combined effects of multiple biological factors including genetic and non-genetic causes with gene/environmental interaction. Intensive research and advanced genetic technology has generated a long list of genes and biomarkers involved in alcoholism neuropathology. These markers reflect complex overlapping and competing effects of possibly hundreds of genes which impact brain structure, function, biochemical alcohol processing, sensitivity and risk for dependence.
We compiled a tabular list of clinically relevant genetic biomarkers for alcoholism targeting expression disturbances in the human brain through an extensive search of keywords related to alcoholism, alcohol abuse, and genetics from peer reviewed medical research articles and related nationally sponsored websites. Gene symbols were then placed on high resolution human chromosome ideograms with gene descriptions in tabular form.
We identified 337 clinically relevant genetic biomarkers and candidate genes for alcoholism and alcohol-responsiveness from human brain research. Genetic biomarkers included neurotransmitter pathways associated with brain reward processes for dopaminergic (e.g., DRD2, MAOA, and COMT), serotoninergic (e.g., HTR3A, HTR1B, HTR3B, and SLC6A4), GABAergic (e.g., GABRA1, GABRA2, and GABRG1), glutaminergic (GAD1, GRIK3, and GRIN2C) and opioid (e.g., OPRM1, OPRD1, and OPRK1) pathways which presumably impact reinforcing properties of alcohol. Gene level disturbances in cellular and molecular networks impacted by alcohol and alcoholism pathology include transketolase (TKT), transferrin (TF), and myelin (e.g., MBP, MOBP, and MOG).
High resolution chromosome ideograms provide investigators, physicians, geneticists and counselors a convenient visual image of the distribution of alcoholism genetic biomarkers from brain research with alphabetical listing of genes in tabular form allowing comparison between alcoholism-related phenotypes, and clinically-relevant alcoholism gene(s) at the chromosome band level to guide research, diagnosis, and treatment. Chromosome ideograms may facilitate gene-based personalized counseling of alcohol dependent individuals and their families.
[Display omitted]
•The work provides a current review of clinically relevant genetic biomarkers for alcoholism.•Provides a convenient visual image of the distribution of genes for alcoholism biomarkers at the chromosome band level•Provides an alphabetical listing of genes in tabular form for comparison between alcoholism-related phenotypes and gene loci•Provides a useful resource to guide research, diagnosis, and treatment</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/j.gene.2015.01.064</identifier><identifier>PMID: 25655461</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>alcohol abuse ; Alcoholism ; Alcoholism - genetics ; Alcoholism - metabolism ; alcohols ; biomarkers ; Biomarkers - metabolism ; biomedical research ; Brain ; Brain - metabolism ; Chromosome band location ; chromosomes ; Chromosomes, Human - genetics ; counseling ; Gene ; Gene Expression ; genes ; Genetic Association Studies ; Genetic biomarkers ; Genetic Markers ; Genetic Predisposition to Disease ; geneticists ; High resolution chromosome ideograms ; Humans ; Internet ; myelin sheath ; neuropathology ; neurotransmitters ; phenotype ; physicians ; risk ; transferrin ; transketolase</subject><ispartof>Gene, 2015-04, Vol.560 (2), p.184-194</ispartof><rights>2015 Elsevier B.V.</rights><rights>Copyright © 2015 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-9fd1b85f4f34117138fed8b09736efe3df63cb0b90ee5f34edfd4ded97dbe8143</citedby><cites>FETCH-LOGICAL-c521t-9fd1b85f4f34117138fed8b09736efe3df63cb0b90ee5f34edfd4ded97dbe8143</cites><orcidid>0000-0001-9283-7809</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378111915001213$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25655461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manzardo, Ann M.</creatorcontrib><creatorcontrib>McGuire, Austen</creatorcontrib><creatorcontrib>Butler, Merlin G.</creatorcontrib><title>Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms</title><title>Gene</title><addtitle>Gene</addtitle><description>Alcoholism arises from combined effects of multiple biological factors including genetic and non-genetic causes with gene/environmental interaction. Intensive research and advanced genetic technology has generated a long list of genes and biomarkers involved in alcoholism neuropathology. These markers reflect complex overlapping and competing effects of possibly hundreds of genes which impact brain structure, function, biochemical alcohol processing, sensitivity and risk for dependence.
We compiled a tabular list of clinically relevant genetic biomarkers for alcoholism targeting expression disturbances in the human brain through an extensive search of keywords related to alcoholism, alcohol abuse, and genetics from peer reviewed medical research articles and related nationally sponsored websites. Gene symbols were then placed on high resolution human chromosome ideograms with gene descriptions in tabular form.
We identified 337 clinically relevant genetic biomarkers and candidate genes for alcoholism and alcohol-responsiveness from human brain research. Genetic biomarkers included neurotransmitter pathways associated with brain reward processes for dopaminergic (e.g., DRD2, MAOA, and COMT), serotoninergic (e.g., HTR3A, HTR1B, HTR3B, and SLC6A4), GABAergic (e.g., GABRA1, GABRA2, and GABRG1), glutaminergic (GAD1, GRIK3, and GRIN2C) and opioid (e.g., OPRM1, OPRD1, and OPRK1) pathways which presumably impact reinforcing properties of alcohol. Gene level disturbances in cellular and molecular networks impacted by alcohol and alcoholism pathology include transketolase (TKT), transferrin (TF), and myelin (e.g., MBP, MOBP, and MOG).
High resolution chromosome ideograms provide investigators, physicians, geneticists and counselors a convenient visual image of the distribution of alcoholism genetic biomarkers from brain research with alphabetical listing of genes in tabular form allowing comparison between alcoholism-related phenotypes, and clinically-relevant alcoholism gene(s) at the chromosome band level to guide research, diagnosis, and treatment. Chromosome ideograms may facilitate gene-based personalized counseling of alcohol dependent individuals and their families.
[Display omitted]
•The work provides a current review of clinically relevant genetic biomarkers for alcoholism.•Provides a convenient visual image of the distribution of genes for alcoholism biomarkers at the chromosome band level•Provides an alphabetical listing of genes in tabular form for comparison between alcoholism-related phenotypes and gene loci•Provides a useful resource to guide research, diagnosis, and treatment</description><subject>alcohol abuse</subject><subject>Alcoholism</subject><subject>Alcoholism - genetics</subject><subject>Alcoholism - metabolism</subject><subject>alcohols</subject><subject>biomarkers</subject><subject>Biomarkers - metabolism</subject><subject>biomedical research</subject><subject>Brain</subject><subject>Brain - metabolism</subject><subject>Chromosome band location</subject><subject>chromosomes</subject><subject>Chromosomes, Human - genetics</subject><subject>counseling</subject><subject>Gene</subject><subject>Gene Expression</subject><subject>genes</subject><subject>Genetic Association Studies</subject><subject>Genetic biomarkers</subject><subject>Genetic Markers</subject><subject>Genetic Predisposition to Disease</subject><subject>geneticists</subject><subject>High resolution chromosome ideograms</subject><subject>Humans</subject><subject>Internet</subject><subject>myelin sheath</subject><subject>neuropathology</subject><subject>neurotransmitters</subject><subject>phenotype</subject><subject>physicians</subject><subject>risk</subject><subject>transferrin</subject><subject>transketolase</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt-L1DAQx4so3t7pP-CD9NGX1kybXwURZFFPOPBFn0OaTLdZ02ZNuiv35L9u6p6HvnhhIDD5zJeZybcoXgCpgQB_va93OGPdEGA1gZpw-qjYgBRdRUgrHxcb0gpZAUB3UVymtCf5MNY8LS4axhmjHDbFz613szPa-9syoseTnpdylV2cKXsXJh2_YUzlEMNULiOWfdRuLnNob8IYvEtT-cMtY64-REw4L3pxYS5zjG63plPwx98pM2aRkMKEpbMYdlFP6VnxZNA-4fO7-6r4-uH9l-11dfP546ftu5vKsAaWqhss9JINdGgpgIBWDmhlTzrRchywtQNvTU_6jiCyzKAdLLVoO2F7lEDbq-LtWfdw7Ce0JvcZtVeH6PKEtypop_59md2oduGkOBeMCZIFXt0JxPD9iGlRk0sGvdczhmNSTV4uUAGifRAF0QguiRTNwyjnhFIKRGa0OaMmhpQiDvfNA1GrH9RerR-nVj8oAir7IRe9_Hvs-5I_BsjAmzOAefknh1El43A2aF1Esygb3P_0fwGw5st5</recordid><startdate>20150415</startdate><enddate>20150415</enddate><creator>Manzardo, Ann M.</creator><creator>McGuire, Austen</creator><creator>Butler, Merlin G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9283-7809</orcidid></search><sort><creationdate>20150415</creationdate><title>Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms</title><author>Manzardo, Ann M. ; McGuire, Austen ; Butler, Merlin G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-9fd1b85f4f34117138fed8b09736efe3df63cb0b90ee5f34edfd4ded97dbe8143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>alcohol abuse</topic><topic>Alcoholism</topic><topic>Alcoholism - genetics</topic><topic>Alcoholism - metabolism</topic><topic>alcohols</topic><topic>biomarkers</topic><topic>Biomarkers - metabolism</topic><topic>biomedical research</topic><topic>Brain</topic><topic>Brain - metabolism</topic><topic>Chromosome band location</topic><topic>chromosomes</topic><topic>Chromosomes, Human - genetics</topic><topic>counseling</topic><topic>Gene</topic><topic>Gene Expression</topic><topic>genes</topic><topic>Genetic Association Studies</topic><topic>Genetic biomarkers</topic><topic>Genetic Markers</topic><topic>Genetic Predisposition to Disease</topic><topic>geneticists</topic><topic>High resolution chromosome ideograms</topic><topic>Humans</topic><topic>Internet</topic><topic>myelin sheath</topic><topic>neuropathology</topic><topic>neurotransmitters</topic><topic>phenotype</topic><topic>physicians</topic><topic>risk</topic><topic>transferrin</topic><topic>transketolase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manzardo, Ann M.</creatorcontrib><creatorcontrib>McGuire, Austen</creatorcontrib><creatorcontrib>Butler, Merlin G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manzardo, Ann M.</au><au>McGuire, Austen</au><au>Butler, Merlin G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>2015-04-15</date><risdate>2015</risdate><volume>560</volume><issue>2</issue><spage>184</spage><epage>194</epage><pages>184-194</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Alcoholism arises from combined effects of multiple biological factors including genetic and non-genetic causes with gene/environmental interaction. Intensive research and advanced genetic technology has generated a long list of genes and biomarkers involved in alcoholism neuropathology. These markers reflect complex overlapping and competing effects of possibly hundreds of genes which impact brain structure, function, biochemical alcohol processing, sensitivity and risk for dependence.
We compiled a tabular list of clinically relevant genetic biomarkers for alcoholism targeting expression disturbances in the human brain through an extensive search of keywords related to alcoholism, alcohol abuse, and genetics from peer reviewed medical research articles and related nationally sponsored websites. Gene symbols were then placed on high resolution human chromosome ideograms with gene descriptions in tabular form.
We identified 337 clinically relevant genetic biomarkers and candidate genes for alcoholism and alcohol-responsiveness from human brain research. Genetic biomarkers included neurotransmitter pathways associated with brain reward processes for dopaminergic (e.g., DRD2, MAOA, and COMT), serotoninergic (e.g., HTR3A, HTR1B, HTR3B, and SLC6A4), GABAergic (e.g., GABRA1, GABRA2, and GABRG1), glutaminergic (GAD1, GRIK3, and GRIN2C) and opioid (e.g., OPRM1, OPRD1, and OPRK1) pathways which presumably impact reinforcing properties of alcohol. Gene level disturbances in cellular and molecular networks impacted by alcohol and alcoholism pathology include transketolase (TKT), transferrin (TF), and myelin (e.g., MBP, MOBP, and MOG).
High resolution chromosome ideograms provide investigators, physicians, geneticists and counselors a convenient visual image of the distribution of alcoholism genetic biomarkers from brain research with alphabetical listing of genes in tabular form allowing comparison between alcoholism-related phenotypes, and clinically-relevant alcoholism gene(s) at the chromosome band level to guide research, diagnosis, and treatment. Chromosome ideograms may facilitate gene-based personalized counseling of alcohol dependent individuals and their families.
[Display omitted]
•The work provides a current review of clinically relevant genetic biomarkers for alcoholism.•Provides a convenient visual image of the distribution of genes for alcoholism biomarkers at the chromosome band level•Provides an alphabetical listing of genes in tabular form for comparison between alcoholism-related phenotypes and gene loci•Provides a useful resource to guide research, diagnosis, and treatment</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>25655461</pmid><doi>10.1016/j.gene.2015.01.064</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-9283-7809</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-1119 |
| ispartof | Gene, 2015-04, Vol.560 (2), p.184-194 |
| issn | 0378-1119 1879-0038 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6675570 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | alcohol abuse Alcoholism Alcoholism - genetics Alcoholism - metabolism alcohols biomarkers Biomarkers - metabolism biomedical research Brain Brain - metabolism Chromosome band location chromosomes Chromosomes, Human - genetics counseling Gene Gene Expression genes Genetic Association Studies Genetic biomarkers Genetic Markers Genetic Predisposition to Disease geneticists High resolution chromosome ideograms Humans Internet myelin sheath neuropathology neurotransmitters phenotype physicians risk transferrin transketolase |
| title | Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A52%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinically%20relevant%20genetic%20biomarkers%20from%20the%20brain%20in%20alcoholism%20with%20representation%20on%20high%20resolution%20chromosome%20ideograms&rft.jtitle=Gene&rft.au=Manzardo,%20Ann%20M.&rft.date=2015-04-15&rft.volume=560&rft.issue=2&rft.spage=184&rft.epage=194&rft.pages=184-194&rft.issn=0378-1119&rft.eissn=1879-0038&rft_id=info:doi/10.1016/j.gene.2015.01.064&rft_dat=%3Cproquest_pubme%3E1660444108%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1660444108&rft_id=info:pmid/25655461&rft_els_id=S0378111915001213&rfr_iscdi=true |