The Chloride Transporter Na+-K+-Cl- Cotransporter Isoform-1 Contributes to Intracellular Chloride Increases after In Vitro Ischemia

Ischemic episodes in the CNS cause significant disturbances in neuronal ionic homeostasis. To directly measure changes in intracellular Cl- concentration ([Cl-]i) during and after ischemia, we used Clomeleon, a novel ratiometric optical indicator for Cl-. Hippocampal slices from adult transgenic mic...

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Veröffentlicht in:	The Journal of neuroscience 2006-02, Vol.26 (5), p.1396-1406
Hauptverfasser:	Pond, Brooks B, Berglund, Ken, Kuner, Thomas, Feng, Guoping, Augustine, George J, Schwartz-Bloom, Rochelle D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - metabolism Brain Ischemia - pathology Bumetanide - pharmacology Chlorides - analysis Chlorides - metabolism Culture Media Furosemide - pharmacology Glucose - metabolism Hippocampus - cytology Hippocampus - metabolism Hydrogen-Ion Concentration In Vitro Techniques Mice Mice, Inbred C57BL Mice, Transgenic Neurons - metabolism Neurons - pathology Picrotoxin - pharmacology Recombinant Fusion Proteins - genetics Sodium Potassium Chloride Symporter Inhibitors - pharmacology Sodium-Potassium-Chloride Symporters - physiology Solute Carrier Family 12, Member 2
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