Intracellular and Trans-Synaptic Regulation of Glutamatergic Synaptogenesis by EphB Receptors

The majority of mature excitatory synapses in the CNS are found on dendritic spines and contain AMPA- and NMDA-type glutamate receptors apposed to presynaptic specializations. EphB receptor tyrosine kinase signaling has been implicated in both NMDA-type glutamate receptor clustering and dendritic sp...

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Veröffentlicht in:	The Journal of neuroscience 2006-11, Vol.26 (47), p.12152-12164
Hauptverfasser:	Kayser, Matthew S, McClelland, Andrew C, Hughes, Ethan G, Dalva, Matthew B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cerebral Cortex - cytology Disks Large Homolog 4 Protein Embryo, Mammalian Glutamic Acid - metabolism Humans Immunohistochemistry - methods Intracellular Signaling Peptides and Proteins - metabolism Intracellular Space - physiology Luminescent Proteins - metabolism Membrane Proteins - metabolism Mice Mice, Knockout Mutagenesis - physiology Neurons - cytology Organ Culture Techniques Patch-Clamp Techniques - methods Presynaptic Terminals - metabolism Rats Receptor, EphB2 - metabolism Receptors, Eph Family - deficiency Receptors, Eph Family - physiology Receptors, Glutamate - genetics Receptors, Glutamate - metabolism RNA, Small Interfering - metabolism Synapses - physiology Synaptic Transmission - physiology Transfection - methods
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