Differential Contributions of Caenorhabditis elegans Histone Deacetylases to Huntingtin Polyglutamine Toxicity

Expansion of a polyglutamine tract in the huntingtin protein causes neuronal degeneration and death in Huntington's disease patients, but the molecular mechanisms underlying polyglutamine-mediated cell death remain unclear. Previous studies suggest that expanded polyglutamine tracts alter trans...

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Veröffentlicht in:	The Journal of neuroscience 2006-03, Vol.26 (10), p.2830-2838
Hauptverfasser:	Bates, Emily A, Victor, Martin, Jones, Adriana K, Shi, Yang, Hart, Anne C
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Animals Animals, Genetically Modified Caenorhabditis elegans Caenorhabditis elegans - cytology Caenorhabditis elegans - drug effects Caenorhabditis elegans - enzymology Carbocyanines CREB-Binding Protein - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal Enzyme Inhibitors - pharmacology Gene Expression - physiology Histone Deacetylases - classification Histone Deacetylases - physiology Humans Huntingtin Protein Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology Hydroxamic Acids - pharmacology Nerve Degeneration - genetics Nerve Degeneration - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons - drug effects Neurons - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Peptides - metabolism Peptides - toxicity Reverse Transcriptase Polymerase Chain Reaction - methods RNA Interference - physiology RNA, Messenger - metabolism
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