Activation of Opioid Receptor Like-1 Receptor in the Spinal Cord Produces Sex-Specific Antinociception in the Rat: Estrogen Attenuates Antinociception in the Female, whereas Testosterone Is Required for the Expression of Antinociception in the Male

Sex-related differences in the perception and modulation of pain have been reported. The present study is the first to investigate systematically whether activation of opioid receptor-like 1 receptor (ORL1) by orphanin FQ (OFQ) produces sex-specific modulation of spinal nociception and whether estro...

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Veröffentlicht in:	The Journal of neuroscience 2006-12, Vol.26 (50), p.13048-13053
Hauptverfasser:	Claiborne, Jomo, Nag, Subodh, Mokha, Sukhbir S
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - administration & dosage Analgesics - agonists Analgesics - antagonists & inhibitors Analgesics - metabolism Animals Dose-Response Relationship, Drug Estrogens - physiology Female Male Narcotic Antagonists Nociceptin Nociceptin Receptor Opioid Peptides - administration & dosage Opioid Peptides - metabolism Opioid Peptides - pharmacology Orchiectomy Ovariectomy Pain - drug therapy Pain - metabolism Pain Measurement - drug effects Pain Measurement - methods Rats Rats, Sprague-Dawley Receptors, Opioid - agonists Receptors, Opioid - metabolism Receptors, Opioid - physiology Sex Characteristics Spinal Cord - drug effects Spinal Cord - metabolism Testosterone - physiology
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