Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine

In this study, we investigated the role of orexinergic systems in dopamine-related behaviors induced by the mu-opioid receptor agonist morphine in rodents. Extensive coexpression of tyrosine hydroxylase with orexin receptors was observed in the mouse ventral tegmental area (VTA). The levels of dopam...

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Veröffentlicht in:	The Journal of neuroscience 2006-01, Vol.26 (2), p.398-405
Hauptverfasser:	Narita, Minoru, Nagumo, Yasuyuki, Hashimoto, Seiko, Narita, Michiko, Khotib, Junaidi, Miyatake, Mayumi, Sakurai, Takeshi, Yanagisawa, Masashi, Nakamachi, Tomoya, Shioda, Seiji, Suzuki, Tsutomu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral/Systems/Cognitive Benzoxazoles - pharmacology Conditioning, Operant - drug effects Desipramine - pharmacology Dopamine - physiology Female Haloperidol - pharmacology Injections, Intraventricular Injections, Subcutaneous Intracellular Signaling Peptides and Proteins Limbic System - drug effects Limbic System - physiology Male Mice Mice, Inbred C57BL Mice, Inbred ICR Mice, Knockout Microdialysis Microinjections Morphine - pharmacology Motor Activity - drug effects Neuropeptides - deficiency Neuropeptides - genetics Nucleus Accumbens - drug effects Nucleus Accumbens - physiology Orexins Oxidopamine - toxicity Protein Precursors - deficiency Protein Precursors - genetics Rats Rats, Sprague-Dawley Receptors, Opioid, mu - agonists Receptors, Opioid, mu - physiology Reward RNA, Messenger - biosynthesis Tyrosine 3-Monooxygenase - analysis Urea - analogs & derivatives Urea - pharmacology Ventral Tegmental Area - drug effects Ventral Tegmental Area - physiology
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