Phenotype of Striatofugal Medium Spiny Neurons in Parkinsonian and Dyskinetic Nonhuman Primates: A Call for a Reappraisal of the Functional Organization of the Basal Ganglia

The classic view of anatomofunctional organization of the basal ganglia is that striatopallidal neurons of the "indirect" pathway express D2 dopamine receptors and corelease enkephalin with GABA, whereas striatopallidal neurons of the "direct" pathway bear D1 dopamine receptors a...

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Veröffentlicht in:	The Journal of neuroscience 2006-08, Vol.26 (34), p.8653-8661
Hauptverfasser:	Nadjar, Agnes, Brotchie, Jonathan M, Guigoni, Celine, Li, Qin, Zhou, Shao-Bo, Wang, Gui-Jie, Ravenscroft, Paula, Georges, Francois, Crossman, Alan R, Bezard, Erwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal Ganglia - physiopathology Cholera Toxin - administration & dosage Cholera Toxin - pharmacokinetics Corpus Striatum - metabolism Corpus Striatum - pathology Corpus Striatum - physiopathology Dyskinesias - pathology Dyskinesias - physiopathology Female Globus Pallidus - metabolism Immunohistochemistry Injections Macaca fascicularis Macaca mulatta Neurons - metabolism Opioid Peptides - metabolism Parkinsonian Disorders - pathology Parkinsonian Disorders - physiopathology Phenotype Primates Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Receptors, Neurokinin-1 - metabolism Synaptic Transmission Tissue Distribution
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