Neuregulin 1-erbB Signaling Is Necessary for Normal Myelination and Sensory Function

To investigate the role of erbB signaling in the interactions between peripheral axons and myelinating Schwann cells, we generated transgenic mice expressing a dominant-negative erbB receptor in these glial cells. Mutant mice have delayed onset of myelination, thinner myelin, shorter internodal leng...

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Veröffentlicht in:	The Journal of neuroscience 2006-03, Vol.26 (12), p.3079-3086
Hauptverfasser:	Chen, Suzhen, Velardez, Miguel Omar, Warot, Xavier, Yu, Zhao-Xue, Miller, Shyra J, Cros, Didier, Corfas, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons - metabolism Axons - pathology Cell Communication - genetics Cell Differentiation - genetics Disease Models, Animal Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Mice Mice, Transgenic Myelin P0 Protein - biosynthesis Myelin P0 Protein - genetics Myelin Proteins - biosynthesis Myelin Proteins - genetics Myelin Sheath - genetics Myelin Sheath - metabolism Nerve Fibers, Myelinated - metabolism Nerve Fibers, Myelinated - pathology Neural Conduction - genetics Neuregulin-1 - genetics Neuregulin-1 - metabolism Neuregulin-1 - pharmacology Oncogene Proteins v-erbB - genetics Peripheral Nerves - growth & development Peripheral Nerves - metabolism Peripheral Nerves - pathology Peripheral Nervous System Diseases - genetics Peripheral Nervous System Diseases - metabolism Peripheral Nervous System Diseases - physiopathology Protein Isoforms - genetics Protein Isoforms - metabolism Protein Isoforms - pharmacology Schwann Cells - metabolism Schwann Cells - pathology Sciatic Nerve - growth & development Sciatic Nerve - metabolism Sciatic Nerve - pathology Sensation - genetics
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