Regulation of Dendritic Branching and Spine Maturation by Semaphorin3A-Fyn Signaling

A member of semaphorin family, semaphorin3A (Sema3A), acts as a chemorepellent or chemoattractant on a wide variety of axons and dendrites in the development of the nervous systems. We here show that Sema3A induces clustering of both postsynaptic density-95 (PSD-95) and presynaptic synapsin I in cul...

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Veröffentlicht in:	The Journal of neuroscience 2006-03, Vol.26 (11), p.2971-2980
Hauptverfasser:	Morita, Asa, Yamashita, Naoya, Sasaki, Yukio, Uchida, Yutaka, Nakajima, Oumi, Nakamura, Fumio, Yagi, Takeshi, Taniguchi, Masahiko, Usui, Hiroshi, Katoh-Semba, Ritsuko, Takei, Kohtaro, Goshima, Yoshio
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Cells, Cultured - drug effects Cells, Cultured - metabolism Cells, Cultured - ultrastructure Cerebral Cortex - cytology Dendrites - drug effects Dendrites - ultrastructure Disks Large Homolog 4 Protein Genotype Guanylate Kinases Intracellular Signaling Peptides and Proteins - metabolism Membrane Proteins - metabolism Mice Mice, Inbred ICR Mice, Knockout Morphogenesis - drug effects Neurons - drug effects Neurons - ultrastructure Phosphorylation - drug effects Presynaptic Terminals - metabolism Protein Processing, Post-Translational - drug effects Proto-Oncogene Proteins c-fyn - antagonists & inhibitors Proto-Oncogene Proteins c-fyn - deficiency Proto-Oncogene Proteins c-fyn - genetics Proto-Oncogene Proteins c-fyn - physiology Pyrazoles - pharmacology Pyrimidines - pharmacology Semaphorin-3A - biosynthesis Semaphorin-3A - deficiency Semaphorin-3A - genetics Semaphorin-3A - pharmacology Semaphorin-3A - physiology Signal Transduction - physiology Synapsins - metabolism
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