Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling
Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic...
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| Veröffentlicht in: | The Journal of neuroscience 2007-08, Vol.27 (35), p.9400-9407 |
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| creator | Jessberger, Sebastian Zhao, Chunmei Toni, Nicolas Clemenson, Gregory D., Jr Li, Yan Gage, Fred H |
| description | Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process. |
| doi_str_mv | 10.1523/JNEUROSCI.2002-07.2007 |
| format | Article |
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A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process.</description><identifier>ISSN: 0270-6474</identifier><identifier>EISSN: 1529-2401</identifier><identifier>DOI: 10.1523/JNEUROSCI.2002-07.2007</identifier><identifier>PMID: 17728453</identifier><language>eng</language><publisher>United States: Soc Neuroscience</publisher><subject>Animals ; Behavior, Animal ; Cell Proliferation - drug effects ; Dendritic Spines - metabolism ; Dendritic Spines - pathology ; Dendritic Spines - ultrastructure ; Female ; Genetic Vectors - physiology ; Green Fluorescent Proteins - metabolism ; Hippocampus - pathology ; Kainic Acid ; Male ; Microscopy, Electron, Transmission - methods ; Microtubule-Associated Proteins - metabolism ; Neurons - metabolism ; Neurons - physiology ; Neurons - ultrastructure ; Neuropeptides - metabolism ; Organogenesis ; Proto-Oncogene Proteins c-fos - metabolism ; Rats ; Rats, Inbred F344 ; Retroviridae - physiology ; Seizures - chemically induced ; Seizures - pathology ; Seizures - physiopathology ; Time Factors</subject><ispartof>The Journal of neuroscience, 2007-08, Vol.27 (35), p.9400-9407</ispartof><rights>Copyright © 2007 Society for Neuroscience 0270-6474/07/279400-08$15.00/0 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-59eaa7457d3377741f09f92253ad3e263eb76c1d485557aeca5258e4eec0515b3</citedby><cites>FETCH-LOGICAL-c528t-59eaa7457d3377741f09f92253ad3e263eb76c1d485557aeca5258e4eec0515b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673128/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6673128/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17728453$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jessberger, Sebastian</creatorcontrib><creatorcontrib>Zhao, Chunmei</creatorcontrib><creatorcontrib>Toni, Nicolas</creatorcontrib><creatorcontrib>Clemenson, Gregory D., Jr</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Gage, Fred H</creatorcontrib><title>Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling</title><title>The Journal of neuroscience</title><addtitle>J Neurosci</addtitle><description>Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process.</description><subject>Animals</subject><subject>Behavior, Animal</subject><subject>Cell Proliferation - drug effects</subject><subject>Dendritic Spines - metabolism</subject><subject>Dendritic Spines - pathology</subject><subject>Dendritic Spines - ultrastructure</subject><subject>Female</subject><subject>Genetic Vectors - physiology</subject><subject>Green Fluorescent Proteins - metabolism</subject><subject>Hippocampus - pathology</subject><subject>Kainic Acid</subject><subject>Male</subject><subject>Microscopy, Electron, Transmission - methods</subject><subject>Microtubule-Associated Proteins - metabolism</subject><subject>Neurons - metabolism</subject><subject>Neurons - physiology</subject><subject>Neurons - ultrastructure</subject><subject>Neuropeptides - metabolism</subject><subject>Organogenesis</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Retroviridae - physiology</subject><subject>Seizures - chemically induced</subject><subject>Seizures - pathology</subject><subject>Seizures - physiopathology</subject><subject>Time Factors</subject><issn>0270-6474</issn><issn>1529-2401</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUtv1DAUhS0EotPCX6i8gg0pfsbJBmkUFSgaWmlK15bj3JkYeZJiO43or6-HGRVYncX97rmPg9A5JRdUMv7x2_Xl3frmtrm6YISwgqi9qhdokat1wQShL9GCMEWKUihxgk5j_EkyQah6jU6oUqwSki-QvwX3OAUoljGO1pkE3Qe8bCEEMyR8DVMYtzBAdBG7AS-7ySe8NinipjfB2ATBPUKHZ5d6vIYUxgcXplh8h-6PF27Ae7wyLXg3bN-gVxvjI7w96hm6-3z5o_larG6-XDXLVWElq1IhazBGCak6zpVSgm5IvakZk9x0HFjJoVWlpZ2opJTKgDWSyQoEgCWSypafoU8H3_up3UFnYUjBeH0f3M6E33o0Tv9fGVyvt-ODLkvFKauywbujQRh_TRCT3rlo8ylmgHGKmuVHVpKSDJYH0IYxxgCb5yGU6H1Q-jkovQ9KE7VXlRvP_13xb9sxmQy8PwC92_azC6DjznifcarneWZKc6lrQQh_AvO_n68</recordid><startdate>20070829</startdate><enddate>20070829</enddate><creator>Jessberger, Sebastian</creator><creator>Zhao, Chunmei</creator><creator>Toni, Nicolas</creator><creator>Clemenson, Gregory D., Jr</creator><creator>Li, Yan</creator><creator>Gage, Fred H</creator><general>Soc Neuroscience</general><general>Society for Neuroscience</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20070829</creationdate><title>Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling</title><author>Jessberger, Sebastian ; Zhao, Chunmei ; Toni, Nicolas ; Clemenson, Gregory D., Jr ; Li, Yan ; Gage, Fred H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c528t-59eaa7457d3377741f09f92253ad3e263eb76c1d485557aeca5258e4eec0515b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Behavior, Animal</topic><topic>Cell Proliferation - drug effects</topic><topic>Dendritic Spines - metabolism</topic><topic>Dendritic Spines - pathology</topic><topic>Dendritic Spines - ultrastructure</topic><topic>Female</topic><topic>Genetic Vectors - physiology</topic><topic>Green Fluorescent Proteins - metabolism</topic><topic>Hippocampus - pathology</topic><topic>Kainic Acid</topic><topic>Male</topic><topic>Microscopy, Electron, Transmission - methods</topic><topic>Microtubule-Associated Proteins - metabolism</topic><topic>Neurons - metabolism</topic><topic>Neurons - physiology</topic><topic>Neurons - ultrastructure</topic><topic>Neuropeptides - metabolism</topic><topic>Organogenesis</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Retroviridae - physiology</topic><topic>Seizures - chemically induced</topic><topic>Seizures - pathology</topic><topic>Seizures - physiopathology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jessberger, Sebastian</creatorcontrib><creatorcontrib>Zhao, Chunmei</creatorcontrib><creatorcontrib>Toni, Nicolas</creatorcontrib><creatorcontrib>Clemenson, Gregory D., Jr</creatorcontrib><creatorcontrib>Li, Yan</creatorcontrib><creatorcontrib>Gage, Fred H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jessberger, Sebastian</au><au>Zhao, Chunmei</au><au>Toni, Nicolas</au><au>Clemenson, Gregory D., Jr</au><au>Li, Yan</au><au>Gage, Fred H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling</atitle><jtitle>The Journal of neuroscience</jtitle><addtitle>J Neurosci</addtitle><date>2007-08-29</date><risdate>2007</risdate><volume>27</volume><issue>35</issue><spage>9400</spage><epage>9407</epage><pages>9400-9407</pages><issn>0270-6474</issn><eissn>1529-2401</eissn><abstract>Seizure activity within the hippocampal circuitry not only affects pre-existing structures, but also dramatically increases the number of newborn granule cells. A retroviral strategy was used to label dividing cells and their progeny in the adult dentate gyrus and to analyze the impact of epileptic activity on adult-generated cells labeled before or after seizures. We show that epileptic activity led to dramatic changes in the neuronal polarity, migration, and integration pattern of newborn granule cells, depending on the time of birth in relation to the epileptic insult. Aberrant neurons were stably integrated into the dentate circuitry, and the consequences on hippocampal neurogenesis were long lasting. The data presented characterized the consequences of seizure-associated plasticity on adult neurogenesis leading to long-term structural changes in the hippocampal circuitry that might represent a pivotal component of the epileptic disease process.</abstract><cop>United States</cop><pub>Soc Neuroscience</pub><pmid>17728453</pmid><doi>10.1523/JNEUROSCI.2002-07.2007</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animals Behavior, Animal Cell Proliferation - drug effects Dendritic Spines - metabolism Dendritic Spines - pathology Dendritic Spines - ultrastructure Female Genetic Vectors - physiology Green Fluorescent Proteins - metabolism Hippocampus - pathology Kainic Acid Male Microscopy, Electron, Transmission - methods Microtubule-Associated Proteins - metabolism Neurons - metabolism Neurons - physiology Neurons - ultrastructure Neuropeptides - metabolism Organogenesis Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Inbred F344 Retroviridae - physiology Seizures - chemically induced Seizures - pathology Seizures - physiopathology Time Factors |
| title | Seizure-Associated, Aberrant Neurogenesis in Adult Rats Characterized with Retrovirus-Mediated Cell Labeling |
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