Mitochondrial Superoxide Production and Nuclear Factor Erythroid 2-Related Factor 2 Activation in p75 Neurotrophin Receptor-Induced Motor Neuron Apoptosis

Nerve growth factor (NGF) can induce apoptosis by signaling through the p75 neurotrophin receptor (p75(NTR)) in several nerve cell populations. Cultured embryonic motor neurons expressing p75(NTR) are not vulnerable to NGF unless they are exposed to an exogenous flux of nitric oxide (*NO). In the pr...

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Veröffentlicht in:	The Journal of neuroscience 2007-07, Vol.27 (29), p.7777-7785
Hauptverfasser:	Pehar, Mariana, Vargas, Marcelo R, Robinson, Kristine M, Cassina, Patricia, Diaz-Amarilla, Pablo J, Hagen, Tory M, Radi, Rafael, Barbeito, Luis, Beckman, Joseph S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Apoptosis - drug effects Apoptosis - physiology Cells, Cultured Cytochromes c - metabolism Embryo, Mammalian Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Mitochondria - drug effects Mitochondria - metabolism Motor Neurons - drug effects Motor Neurons - physiology Nerve Growth Factor - pharmacology NF-E2-Related Factor 2 - metabolism Nitric Oxide Donors - pharmacology Nitroso Compounds - pharmacology Oligodeoxyribonucleotides, Antisense - pharmacology Rats Rats, Sprague-Dawley Reactive Oxygen Species - metabolism Receptor, Nerve Growth Factor - metabolism Sphingomyelin Phosphodiesterase - metabolism Spinal Cord - cytology Superoxide Dismutase - genetics Superoxide Dismutase - pharmacology
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