CNS-Derived Interleukin-4 Is Essential for the Regulation of Autoimmune Inflammation and Induces a State of Alternative Activation in Microglial Cells

Regulation of inflammation in the CNS is essential to prevent irreversible cellular damage that can occur in neurodegenerative diseases such as multiple sclerosis (MS). We investigated the role of interleukin-4 (IL-4) in regulating CNS inflammation using the animal model of MS, experimental autoimmu...

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Veröffentlicht in:	The Journal of neuroscience 2007-10, Vol.27 (40), p.10714-10721
Hauptverfasser:	Ponomarev, Eugene D, Maresz, Katarzyna, Tan, Yanping, Dittel, Bonnie N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-N-Acetylhexosaminidases - metabolism Cells, Cultured Central Nervous System - metabolism Central Nervous System - pathology Encephalomyelitis, Autoimmune, Experimental - etiology Encephalomyelitis, Autoimmune, Experimental - metabolism Encephalomyelitis, Autoimmune, Experimental - pathology Flow Cytometry Gene Expression Regulation - genetics Gene Expression Regulation - physiology Intercellular Signaling Peptides and Proteins Interleukin-4 - deficiency Interleukin-4 - physiology Lectins - metabolism Macrophages Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microglia - physiology Nerve Growth Factor - genetics Nerve Growth Factor - metabolism Nitric Oxide Proteins - genetics Proteins - metabolism Receptors, Cell Surface - deficiency Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - biosynthesis
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