A New Binding Motif for the Transcriptional Repressor REST Uncovers Large Gene Networks Devoted to Neuronal Functions

The repressor element 1 (RE1) silencing transcription factor (REST) helps preserve the identity of nervous tissue by silencing neuronal genes in non-neural tissues. Moreover, in an epithelial model of tumorigenesis, loss of REST function is associated with loss of adhesion, suggesting the aberrant e...

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Veröffentlicht in:	The Journal of neuroscience 2007-06, Vol.27 (25), p.6729-6739
Hauptverfasser:	Otto, Stefanie J, McCorkle, Sean R, Hover, John, Conaco, Cecilia, Han, Jong-Jin, Impey, Soren, Yochum, Gregory S, Dunn, John J, Goodman, Richard H, Mandel, Gail
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Animals Binding Sites - physiology Cell Line Gene Expression Profiling Gene Regulatory Networks - physiology Mice Neurons - metabolism Neurons - physiology Repressor Proteins - biosynthesis Repressor Proteins - genetics Repressor Proteins - metabolism Transcription Factors - biosynthesis Transcription Factors - genetics Transcription Factors - metabolism
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