Reduced Expression of A-Type Potassium Channels in Primary Sensory Neurons Induces Mechanical Hypersensitivity

A-type K+ channels (A-channels) are crucial in controlling neuronal excitability, and their downregulation in pain-sensing neurons may increase pain sensation. To test this hypothesis, we first characterized the expression of two A-channels, Kv3.4 and Kv4.3, in rat dorsal root ganglion (DRG) neurons...

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Veröffentlicht in:	The Journal of neuroscience 2007-09, Vol.27 (37), p.9855-9865
Hauptverfasser:	Chien, Li-Ying, Cheng, Jen-Kun, Chu, Dachen, Cheng, Chau-Fu, Tsaur, Meei-Ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gene Expression Regulation - physiology Male Neurons, Afferent - metabolism Pain - genetics Pain - metabolism Pain Measurement - methods Physical Stimulation - methods Rats Rats, Sprague-Dawley Shal Potassium Channels - antagonists & inhibitors Shal Potassium Channels - biosynthesis Shal Potassium Channels - genetics Shaw Potassium Channels - antagonists & inhibitors Shaw Potassium Channels - biosynthesis Shaw Potassium Channels - genetics Spinal Cord - metabolism
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