Spike Timing Amplifies the Effect of Electric Fields on Neurons: Implications for Endogenous Field Effects
Despite compelling phenomenological evidence that small electric fields (
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| Veröffentlicht in: | The Journal of neuroscience 2007-03, Vol.27 (11), p.3030-3036 |
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| container_end_page | 3036 |
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| container_issue | 11 |
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| container_title | The Journal of neuroscience |
| container_volume | 27 |
| creator | Radman, Thomas Su, Yuzhuo An, Je Hi Parra, Lucas C Bikson, Marom |
| description | Despite compelling phenomenological evidence that small electric fields ( |
| doi_str_mv | 10.1523/JNEUROSCI.0095-07.2007 |
| format | Article |
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Here we demonstrate a novel mechanism by which the nonlinear properties of single neurons "amplify" the effect of small electric fields: when concurrent to suprathreshold synaptic input, small electric fields can have significant effects on spike timing. For low-frequency fields, our theory predicts a linear dependency of spike timing changes on field strength. For high-frequency fields (relative to the synaptic input), the theory predicts coherent firing, with mean firing phase and coherence each increasing monotonically with field strength. Importantly, in both cases, the effects of fields on spike timing are amplified with decreasing synaptic input slope and increased cell susceptibility (millivolt membrane polarization per field amplitude). We confirmed these predictions experimentally using CA1 hippocampal neurons in vitro exposed to static (direct current) and oscillating (alternating current) uniform electric fields. In addition, we develop a robust method to quantify cell susceptibility using spike timing. 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| ispartof | The Journal of neuroscience, 2007-03, Vol.27 (11), p.3030-3036 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Action Potentials - physiology Animals Biological Clocks - physiology Electric Stimulation - methods Male Neurons - physiology Rats Rats, Sprague-Dawley Time Factors |
| title | Spike Timing Amplifies the Effect of Electric Fields on Neurons: Implications for Endogenous Field Effects |
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