MrgD Activation Inhibits KCNQ/M-Currents and Contributes to Enhanced Neuronal Excitability

The recently identified Mas-related gene (Mrg) family of G-protein-coupled receptors is expressed almost exclusively in dorsal root ganglion (DRG) neurons. The expression of one family member, MrgD, is even further confined to IB4+, nonpeptidergic, small-diameter nociceptors. Although the functional...

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Veröffentlicht in:	The Journal of neuroscience 2007-04, Vol.27 (16), p.4492-4496
Hauptverfasser:	Crozier, Robert A, Ajit, Seena K, Kaftan, Edward J, Pausch, Mark H
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals CHO Cells Cricetinae Cricetulus Ganglia, Spinal - metabolism KCNQ2 Potassium Channel - metabolism KCNQ3 Potassium Channel - metabolism Male Neurons - physiology Patch-Clamp Techniques Rats Rats, Long-Evans Rats, Sprague-Dawley Receptors, G-Protein-Coupled - metabolism
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