Biphasic Coupling of Neuronal Nitric Oxide Synthase Phosphorylation to the NMDA Receptor Regulates AMPA Receptor Trafficking and Neuronal Cell Death

Postsynaptic nitric oxide (NO) production affects synaptic plasticity and neuronal cell death. Ca2+ fluxes through the NMDA receptor (NMDAR) stimulate the production of NO by neuronal nitric oxide synthase (nNOS). However, the mechanisms by which nNOS activity is regulated are poorly understood. We...

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Veröffentlicht in:	The Journal of neuroscience 2007-03, Vol.27 (13), p.3445-3455
Hauptverfasser:	Rameau, Gerald A, Tukey, David S, Garcin-Hosfield, Elsa D, Titcombe, Roseann F, Misra, Charu, Khatri, Latika, Getzoff, Elizabeth D, Ziff, Edward B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death - physiology Cells, Cultured Cerebral Cortex - embryology Cerebral Cortex - metabolism Glutamic Acid - metabolism Hippocampus - embryology Hippocampus - metabolism Neurons - enzymology Nitric Oxide Synthase - metabolism Phosphorylation Protein Transport - physiology Rats Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - metabolism
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