Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity

Alzheimer's disease is an age-related neurodegenerative disorder with its toxicity linked to the generation of amyloid-β peptide (Aβ). Within the Aβ sequence, there is a systemic repeat of a GxxxG motif, which theoretical studies have suggested may be involved in both peptide aggregation and me...

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Veröffentlicht in:	The Journal of neuroscience 2008-11, Vol.28 (46), p.11950-11958
Hauptverfasser:	Hung, Lin Wai, Ciccotosto, Giuseppe D., Giannakis, Eleni, Tew, Deborah J., Perez, Keyla, Masters, Colin L., Cappai, Roberto, Wade, John D., Barnham, Kevin J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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