Long-Distance Retrograde Effects of Botulinum Neurotoxin A

Botulinum neurotoxins (designated BoNT/A-BoNT/G) are bacterial enzymes that block neurotransmitter release by cleaving essential components of the vesicle fusion machinery. BoNT/A, which cleaves SNAP-25 (synaptosomal-associated protein of 25 kDa), is extensively exploited in clinical medicine to tre...

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Veröffentlicht in:	The Journal of neuroscience 2008-04, Vol.28 (14), p.3689-3696
Hauptverfasser:	Antonucci, Flavia, Rossi, Chiara, Gianfranceschi, Laura, Rossetto, Ornella, Caleo, Matteo
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Action Potentials - physiology Animals Botulinum Toxins, Type A - administration & dosage Botulinum Toxins, Type A - metabolism Dose-Response Relationship, Drug Functional Laterality Limbic System - cytology Limbic System - drug effects Mice Mice, Inbred C57BL Nerve Tissue Proteins - metabolism Neural Pathways - drug effects Neural Pathways - metabolism Neurons - drug effects Neurons - metabolism Neurotoxins - administration & dosage Neurotoxins - metabolism Protein Transport - physiology Rats Rats, Sprague-Dawley Synaptosomal-Associated Protein 25 - metabolism Time Factors Vibrissae - innervation Visual Pathways - drug effects Visual Pathways - metabolism Visual Pathways - physiology
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