A New Nerve Growth Factor-Mimetic Peptide Active on Neuropathic Pain in Rats

Analysis of the structure of nerve growth factor (NGF)-tyrosine kinase receptor A (TrkA) complex, site-directed mutagenesis studies and results from chemical modification of amino acid residues have identified loop 1, loop 4, and the N-terminal region of the NGF molecule as the most relevant for its...

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Veröffentlicht in:	The Journal of neuroscience 2008-03, Vol.28 (11), p.2698-2709
Hauptverfasser:	Colangelo, Anna Maria, Bianco, Maria Rosaria, Vitagliano, Luigi, Cavaliere, Carlo, Cirillo, Giovanni, De Gioia, Luca, Diana, Donatella, Colombo, Daniele, Redaelli, Cristina, Zaccaro, Laura, Morelli, Giancarlo, Papa, Michele, Sarmientos, Paolo, Alberghina, Lilia, Martegani, Enzo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomimetic Materials - pharmacology Biomimetic Materials - therapeutic use Cells, Cultured Chick Embryo Humans Male Mice Nerve Growth Factor - agonists Nerve Growth Factor - pharmacology Nerve Growth Factor - therapeutic use Pain - drug therapy Pain - metabolism Pain Measurement - drug effects Pain Measurement - methods PC12 Cells Peptides - chemical synthesis Peptides - pharmacology Peptides - therapeutic use Peripheral Nervous System Diseases - drug therapy Peripheral Nervous System Diseases - metabolism Rats Rats, Sprague-Dawley Sciatic Neuropathy - drug therapy Sciatic Neuropathy - metabolism
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