Glial Dysfunction in Parkin Null Mice: Effects of Aging

Parkin mutations in humans produce parkinsonism whose pathogenesis is related to impaired protein degradation, increased free radicals, and abnormal neurotransmitter release. The role of glia in parkin deficiency is little known. We cultured midbrain glia from wild-type (WT) and parkin knock-out (PK...

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Veröffentlicht in:	The Journal of neuroscience 2008-01, Vol.28 (3), p.598-611
Hauptverfasser:	Solano, Rosa M, Casarejos, Maria J, Menendez-Cuervo, Jamie, Rodriguez-Navarro, Jose A, Garcia de Yebenes, Justo, Mena, Maria A
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - physiology Analysis of Variance Animals bcl-X Protein - metabolism CD11 Antigens - metabolism Cells, Cultured Culture Media, Conditioned - pharmacology Dose-Response Relationship, Drug Embryo, Mammalian Glial Fibrillary Acidic Protein - metabolism Glutathione - metabolism Glutathione - pharmacology L-Lactate Dehydrogenase - metabolism Mesencephalon - cytology Mice Mice, Knockout Neuroglia - chemistry Neuroglia - classification Neuroglia - pathology Neuroglia - physiology Neurons - classification Neurons - drug effects Neurons - physiology Oxidative Stress - physiology Signal Transduction - drug effects Signal Transduction - physiology Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics
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