Phosphorylation of GMFγ by c-Abl Coordinates Lamellipodial and Focal Adhesion Dynamics to Regulate Airway Smooth Muscle Cell Migration

Airway smooth muscle cells require coordinated protrusion and focal adhesion dynamics to migrate properly. However, the signaling cascades that connect these two processes remain incompletely understood. Glia maturation factor (GMF)-γ has been implicated in inducing actin debranching and inhibiting...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2019-08, Vol.61 (2), p.219-231
Hauptverfasser:	Gerlach, Brennan D, Tubbesing, Kate, Liao, Guoning, Rezey, Alyssa C, Wang, Ruping, Barroso, Margarida, Tang, Dale D
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Asthma Binding sites Bronchi - metabolism Cell Adhesion Cell adhesion & migration Cell migration Cell Movement Cells, Cultured Extracellular matrix Focal Adhesions - metabolism Gene Expression Regulation Glia maturation factor Glia Maturation Factor - metabolism Humans Image processing Localization Microscopy Microscopy, Fluorescence Muscle Contraction Mutation Myocytes, Smooth Muscle - cytology Myosin N-WASP protein Open source software Original Research Phosphorylation Protein-tyrosine kinase Proteins Proto-Oncogene Proteins c-abl - metabolism Pseudopodia - metabolism Respiratory tract Signal Transduction Smooth muscle Software Trachea - metabolism Wiskott-Aldrich Syndrome Protein, Neuronal - metabolism Zyxin - metabolism
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