Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV

HIV integrates its provirus into the host genome and establishes latent infection. Antiretroviral therapy (ART) can control HIV viremia, but cannot eradicate or cure the virus. Approaches targeting host epigenetic machinery to repress HIV, leading to an aviremic state free of ART, are needed. Bromod...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2019-08, Vol.129 (8), p.3361-3373
Hauptverfasser:	Niu, Qingli, Liu, Zhiqing, Alamer, Edrous, Fan, Xiuzhen, Chen, Haiying, Endsley, Janice, Gelman, Benjamin B, Tian, Bing, Kim, Jerome H, Michael, Nelson L, Robb, Merlin L, Ananworanich, Jintanat, Zhou, Jia, Hu, Haitao
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Anti-Retroviral Agents - chemistry Anti-Retroviral Agents - pharmacology Antiretroviral agents Antiretroviral therapy Azepines - chemistry Azepines - pharmacology Biomedical research Cell culture Cell cycle Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromatin Control DNA probes Drug Design Drug development Drug resistance Drug therapy Efavirenz Epigenetic inheritance Epigenetics Female Gene expression Gene regulation Genomes Genomics Health aspects Highly active antiretroviral therapy HIV HIV Infections - drug therapy HIV Infections - genetics HIV Infections - metabolism HIV Infections - pathology HIV-1 - genetics HIV-1 - metabolism Human immunodeficiency virus Humans Infection Infections Latent infection Male Protein binding Protein Domains Proteins Raltegravir RNA polymerase Structure-Activity Relationship tat Gene Products, Human Immunodeficiency Virus - genetics tat Gene Products, Human Immunodeficiency Virus - metabolism Tat protein Transcription elongation Transcription Factors - antagonists & inhibitors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Triazoles - chemistry Triazoles - pharmacology Viremia Virus diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!