The flavonoid, 2′-methoxy-6-methylflavone, affords neuroprotection following focal cerebral ischaemia

Tonic inhibitory currents, mediated by extrasynaptic GABAA receptors, are elevated at a delay following stroke. Flavonoids minimise the extent of cellular damage following stroke, but little is known about their mode of action. We demonstrate that the flavonoid, 2′-methoxy-6-methylflavone (0.1–10 µM...

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Veröffentlicht in:	Journal of cerebral blood flow and metabolism 2019-07, Vol.39 (7), p.1266-1282
Hauptverfasser:	Clarkson, Andrew N, Boothman-Burrell, Lily, Dósa, Zita, Nagaraja, Raghavendra Y, Jin, Liang, Parker, Kim, van Nieuwenhuijzen, Petra S, Neumann, Silke, Gowing, Emma K, Gavande, Navnath, Ahring, Philip K, Holm, Mai M, Hanrahan, Jane R, Nicolazzo, Joseph A, Jensen, Kimmo, Chebib, Mary
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Brain Ischemia - drug therapy Disease Models, Animal Flavones - administration & dosage Flavones - pharmacokinetics GABA Modulators - administration & dosage Male Mice Mice, Inbred BALB C Mice, Knockout Neuroprotective Agents - administration & dosage Original Receptors, GABA-A - drug effects Receptors, GABA-A - genetics Receptors, GABA-A - physiology Stroke - drug therapy Synaptic Potentials - drug effects Synaptic Potentials - physiology
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