Synaptic Activity Induces Dramatic Changes in the Geometry of the Cell Nucleus: Interplay between Nuclear Structure, Histone H3 Phosphorylation, and Nuclear Calcium Signaling

Synaptic activity initiates many adaptive responses in neurons. Here we report a novel form of structural plasticity in dissociated hippocampal cultures and slice preparations. Using a recently developed algorithm for three-dimensional image reconstruction and quantitative measurements of cell organ...

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Veröffentlicht in:	The Journal of neuroscience 2009-11, Vol.29 (47), p.14687-14700
Hauptverfasser:	Wittmann, Malte, Queisser, Gillian, Eder, Anja, Wiegert, J. Simon, Bengtson, C. Peter, Hellwig, Andrea, Wittum, Gabriel, Bading, Hilmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals Animals, Newborn Apoptosis - physiology Calcium Signaling - physiology Cell Compartmentation - physiology Cell Nucleus - metabolism Cell Nucleus - ultrastructure Cell Shape - physiology Cells, Cultured Cytosol - metabolism Hippocampus - metabolism Hippocampus - ultrastructure Histones - metabolism MAP Kinase Signaling System - physiology Neurons - metabolism Neurons - ultrastructure Nuclear Envelope - metabolism Nuclear Envelope - ultrastructure Nuclear Pore - metabolism Organ Culture Techniques Phosphorylation Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Serine - metabolism Synaptic Transmission - physiology
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