Reggies/Flotillins Regulate Retinal Axon Regeneration in the Zebrafish Optic Nerve and Differentiation of Hippocampal and N2a Neurons

The reggies/flotillins--proteins upregulated during axon regeneration in retinal ganglion cells (RGCs)--are scaffolding proteins of microdomains and involved in neuronal differentiation. Here, we show that reggies regulate axon regeneration in zebrafish (ZF) after optic nerve section (ONS) in vivo a...

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Veröffentlicht in:	The Journal of neuroscience 2009-05, Vol.29 (20), p.6607-6615
Hauptverfasser:	Munderloh, Christina, Solis, Gonzalo P, Bodrikov, Vsevolod, Jaeger, Friederike A, Wiechers, Marianne, Malaga-Trillo, Edward, Stuermer, Claudia A. O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn cdc42 GTP-Binding Protein - metabolism Cell Differentiation - drug effects Cell Differentiation - genetics Cell Differentiation - physiology Cells, Cultured Dextrans Down-Regulation - drug effects Green Fluorescent Proteins - genetics Hippocampus - cytology Immunoprecipitation Insulin-Like Growth Factor I - pharmacology Membrane Proteins - genetics Membrane Proteins - metabolism Mice Nerve Regeneration - drug effects Nerve Regeneration - genetics Nerve Regeneration - physiology Neuroblastoma Neurons - drug effects Neurons - physiology Oligodeoxyribonucleotides, Antisense - pharmacology Optic Nerve Injuries - metabolism Optic Nerve Injuries - pathology Optic Nerve Injuries - physiopathology Organ Preservation Solutions rac GTP-Binding Proteins - metabolism Retina - pathology Retina - physiology rho GTP-Binding Proteins - metabolism RNA, Small Interfering - metabolism Signal Transduction - drug effects Signal Transduction - genetics Transfection - methods Wiskott-Aldrich Syndrome Protein, Neuronal - metabolism Zebrafish
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