Synaptopodin Regulates Plasticity of Dendritic Spines in Hippocampal Neurons

The spine apparatus is an essential component of dendritic spines of cortical and hippocampal neurons, yet its functions are still enigmatic. Synaptopodin (SP), an actin-binding protein, is tightly associated with the spine apparatus and it may play a role in synaptic plasticity, but it has not yet...

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Veröffentlicht in:	The Journal of neuroscience 2009-01, Vol.29 (4), p.1017-1033
Hauptverfasser:	Vlachos, Andreas, Korkotian, Eduard, Schonfeld, Eldi, Copanaki, Ekaterini, Deller, Thomas, Segal, Menahem
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - pharmacology Actins - metabolism Animals Animals, Newborn Antipyrine - analogs & derivatives Antipyrine - pharmacology Caffeine - pharmacology Calcium - metabolism Cells, Cultured Codeine - pharmacology Dendritic Spines - drug effects Dendritic Spines - physiology Drug Combinations Electric Stimulation - methods Excitatory Amino Acid Agents - pharmacology Green Fluorescent Proteins - genetics Hippocampus - cytology Microfilament Proteins - genetics Microfilament Proteins - physiology Models, Biological Neuronal Plasticity - drug effects Neuronal Plasticity - physiology Neurons - cytology Neurons - drug effects Patch-Clamp Techniques - methods Protein Transport - drug effects Protein Transport - genetics Rats Receptors, AMPA - metabolism RNA, Small Interfering - pharmacology Ryanodine Receptor Calcium Release Channel - metabolism Synaptophysin - metabolism Transfection - methods
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