Peroxynitrite supports a metabolic reprogramming in merlin-deficient Schwann cells and promotes cell survival

Neurofibromatosis type 2 (NF2) is an autosomal-dominant disorder characterized by the development of bilateral vestibular schwannomas. The NF2 gene encodes the tumor suppressor merlin, and loss of merlin activity promotes tumorigenesis and causes NF2. Cellular redox signaling has been implicated in...

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Veröffentlicht in:	The Journal of biological chemistry 2019-07, Vol.294 (30), p.11354-11368
Hauptverfasser:	Pestoni, Jeanine C., Klingeman Plati, Stephani, Valdivia Camacho, Oliver D., Fuse, Marisa A., Onatunde, Maria, Sparrow, Nicklaus A., Karajannis, Matthias A., Fernández-Valle, Cristina, Franco, Maria Clara
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Biology Cell Survival - physiology Cells, Cultured Genes, Tumor Suppressor Glutamine - metabolism Glycolysis Humans Mice Mitochondria - metabolism Neurofibromatosis 2 - genetics Oxidative Phosphorylation Oxygen Consumption Peroxynitrous Acid - physiology Schwann Cells - metabolism
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