CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and a leading cause of cancer-related deaths worldwide. Emerging studies have shown that circular RNAs (circRNAs) are differentially expressed in HCC and play an important role in HCC pathogenesis and metastasis. However, the...
Gespeichert in:
| Veröffentlicht in: | Cell death discovery 2019-07, Vol.5 (1), p.121-9, Article 121 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9 |
|---|---|
| container_issue | 1 |
| container_start_page | 121 |
| container_title | Cell death discovery |
| container_volume | 5 |
| creator | Luo, Yanwei Fu, Yunfeng Huang, Rong Gao, Meng Liu, Fengxia Gui, Rong Nie, Xinmin |
| description | Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and a leading cause of cancer-related deaths worldwide. Emerging studies have shown that circular RNAs (circRNAs) are differentially expressed in HCC and play an important role in HCC pathogenesis and metastasis. However, the mechanism of circRNA in the chemoresistance of HCC remains unclear. In this study, we aimed to investigate the role of circRNA in cisplatin resistance of HCC. We identified a novel circRNA circRNA_101505 that was decreased in cisplatin-resistant HCC tissues and cell lines, and associated with a poor survival outcome. Gain-of-function investigations showed that overexpression of circRNA_101505 suppressed cancer cell growth in vivo and in vitro, and enhanced cisplatin toxicity in HCC cells. Mechanistic studies found that circRNA_101505 could sensitize HCC cells to cisplatin by sponging miR-103, and thereby promoting oxidored-nitro domain-containing protein 1 (NOR1) expression. In conclusion, the significant inhibitory effects indicate circRNA_101505 to be a potential therapeutic target for HCC treatment. Our findings provide significant evidence to further elucidate the therapeutic use of circRNA in HCC. |
| doi_str_mv | 10.1038/s41420-019-0202-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6662675</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2266312293</sourcerecordid><originalsourceid>FETCH-LOGICAL-c536t-6432b17104bb489dcc7cf0ae7c8d16dcc5389061c62c15c92e4cd153e57c6dbe3</originalsourceid><addsrcrecordid>eNp1kd9qFTEQxhdRbKl9AG8k4I030UyySXZvhHLwHxSFotchm51zmrKbrElOaX0WH9Ysp9YqeDVJ5jffzORrmufAXgMT3ZvcQssZZdBTxhmn6lFzzJnsqNagHj84HzWnOV8xxkDqVnfiaXMkQGjOWzhufm58chefzwzUNJMkY8i--B-YySUutkSH07SfbCLOJudDnC1ZnzIpkTifl8kWH8hwS_ISw86HHZn9Ba0TEhtGsqQ4x1LF4o0fY8KRBl9SJGPV8YG6GEqNa1UlC1YlIHizJMzZx_CsebK1U8bTu3jSfHv_7uvmIz3_8uHT5uycOilUoaoVfAANrB2GtutH57TbMovadSOoepWi65kCp7gD6XqOrRtBCpTaqXFAcdK8Pegu-2HG0WEoyU5mSX626dZE683fmeAvzS5eG6UUV1pWgVd3Ail-32MuZvZ5_SYbMO6z4Vx1gsme64q-_Ae9ivsU6norpQRw3otKwYFyKeaccHs_DDCz2m8O9ptqv1ntN6rWvHi4xX3Fb7MrwA9Arqmww_Sn9f9VfwEv1r1o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2266312293</pqid></control><display><type>article</type><title>CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression</title><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><creator>Luo, Yanwei ; Fu, Yunfeng ; Huang, Rong ; Gao, Meng ; Liu, Fengxia ; Gui, Rong ; Nie, Xinmin</creator><creatorcontrib>Luo, Yanwei ; Fu, Yunfeng ; Huang, Rong ; Gao, Meng ; Liu, Fengxia ; Gui, Rong ; Nie, Xinmin</creatorcontrib><description>Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and a leading cause of cancer-related deaths worldwide. Emerging studies have shown that circular RNAs (circRNAs) are differentially expressed in HCC and play an important role in HCC pathogenesis and metastasis. However, the mechanism of circRNA in the chemoresistance of HCC remains unclear. In this study, we aimed to investigate the role of circRNA in cisplatin resistance of HCC. We identified a novel circRNA circRNA_101505 that was decreased in cisplatin-resistant HCC tissues and cell lines, and associated with a poor survival outcome. Gain-of-function investigations showed that overexpression of circRNA_101505 suppressed cancer cell growth in vivo and in vitro, and enhanced cisplatin toxicity in HCC cells. Mechanistic studies found that circRNA_101505 could sensitize HCC cells to cisplatin by sponging miR-103, and thereby promoting oxidored-nitro domain-containing protein 1 (NOR1) expression. In conclusion, the significant inhibitory effects indicate circRNA_101505 to be a potential therapeutic target for HCC treatment. Our findings provide significant evidence to further elucidate the therapeutic use of circRNA in HCC.</description><identifier>ISSN: 2058-7716</identifier><identifier>EISSN: 2058-7716</identifier><identifier>DOI: 10.1038/s41420-019-0202-6</identifier><identifier>PMID: 31372241</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67/1059 ; 692/699/67/1244 ; Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Cell Biology ; Cell Cycle Analysis ; Chemoresistance ; Chemotherapy ; Cisplatin ; Hepatocellular carcinoma ; Life Sciences ; Liver cancer ; Metastases ; Stem Cells ; Therapeutic applications ; Toxicity ; Tumors</subject><ispartof>Cell death discovery, 2019-07, Vol.5 (1), p.121-9, Article 121</ispartof><rights>The Author(s) 2019</rights><rights>2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-6432b17104bb489dcc7cf0ae7c8d16dcc5389061c62c15c92e4cd153e57c6dbe3</citedby><cites>FETCH-LOGICAL-c536t-6432b17104bb489dcc7cf0ae7c8d16dcc5389061c62c15c92e4cd153e57c6dbe3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662675/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662675/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31372241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Yanwei</creatorcontrib><creatorcontrib>Fu, Yunfeng</creatorcontrib><creatorcontrib>Huang, Rong</creatorcontrib><creatorcontrib>Gao, Meng</creatorcontrib><creatorcontrib>Liu, Fengxia</creatorcontrib><creatorcontrib>Gui, Rong</creatorcontrib><creatorcontrib>Nie, Xinmin</creatorcontrib><title>CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression</title><title>Cell death discovery</title><addtitle>Cell Death Discov</addtitle><addtitle>Cell Death Discov</addtitle><description>Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and a leading cause of cancer-related deaths worldwide. Emerging studies have shown that circular RNAs (circRNAs) are differentially expressed in HCC and play an important role in HCC pathogenesis and metastasis. However, the mechanism of circRNA in the chemoresistance of HCC remains unclear. In this study, we aimed to investigate the role of circRNA in cisplatin resistance of HCC. We identified a novel circRNA circRNA_101505 that was decreased in cisplatin-resistant HCC tissues and cell lines, and associated with a poor survival outcome. Gain-of-function investigations showed that overexpression of circRNA_101505 suppressed cancer cell growth in vivo and in vitro, and enhanced cisplatin toxicity in HCC cells. Mechanistic studies found that circRNA_101505 could sensitize HCC cells to cisplatin by sponging miR-103, and thereby promoting oxidored-nitro domain-containing protein 1 (NOR1) expression. In conclusion, the significant inhibitory effects indicate circRNA_101505 to be a potential therapeutic target for HCC treatment. Our findings provide significant evidence to further elucidate the therapeutic use of circRNA in HCC.</description><subject>631/67/1059</subject><subject>692/699/67/1244</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Cell Cycle Analysis</subject><subject>Chemoresistance</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Hepatocellular carcinoma</subject><subject>Life Sciences</subject><subject>Liver cancer</subject><subject>Metastases</subject><subject>Stem Cells</subject><subject>Therapeutic applications</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>2058-7716</issn><issn>2058-7716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kd9qFTEQxhdRbKl9AG8k4I030UyySXZvhHLwHxSFotchm51zmrKbrElOaX0WH9Ysp9YqeDVJ5jffzORrmufAXgMT3ZvcQssZZdBTxhmn6lFzzJnsqNagHj84HzWnOV8xxkDqVnfiaXMkQGjOWzhufm58chefzwzUNJMkY8i--B-YySUutkSH07SfbCLOJudDnC1ZnzIpkTifl8kWH8hwS_ISw86HHZn9Ba0TEhtGsqQ4x1LF4o0fY8KRBl9SJGPV8YG6GEqNa1UlC1YlIHizJMzZx_CsebK1U8bTu3jSfHv_7uvmIz3_8uHT5uycOilUoaoVfAANrB2GtutH57TbMovadSOoepWi65kCp7gD6XqOrRtBCpTaqXFAcdK8Pegu-2HG0WEoyU5mSX626dZE683fmeAvzS5eG6UUV1pWgVd3Ail-32MuZvZ5_SYbMO6z4Vx1gsme64q-_Ae9ivsU6norpQRw3otKwYFyKeaccHs_DDCz2m8O9ptqv1ntN6rWvHi4xX3Fb7MrwA9Arqmww_Sn9f9VfwEv1r1o</recordid><startdate>20190729</startdate><enddate>20190729</enddate><creator>Luo, Yanwei</creator><creator>Fu, Yunfeng</creator><creator>Huang, Rong</creator><creator>Gao, Meng</creator><creator>Liu, Fengxia</creator><creator>Gui, Rong</creator><creator>Nie, Xinmin</creator><general>Nature Publishing Group UK</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PKEHL</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190729</creationdate><title>CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression</title><author>Luo, Yanwei ; Fu, Yunfeng ; Huang, Rong ; Gao, Meng ; Liu, Fengxia ; Gui, Rong ; Nie, Xinmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-6432b17104bb489dcc7cf0ae7c8d16dcc5389061c62c15c92e4cd153e57c6dbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>631/67/1059</topic><topic>692/699/67/1244</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Cell Cycle Analysis</topic><topic>Chemoresistance</topic><topic>Chemotherapy</topic><topic>Cisplatin</topic><topic>Hepatocellular carcinoma</topic><topic>Life Sciences</topic><topic>Liver cancer</topic><topic>Metastases</topic><topic>Stem Cells</topic><topic>Therapeutic applications</topic><topic>Toxicity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Luo, Yanwei</creatorcontrib><creatorcontrib>Fu, Yunfeng</creatorcontrib><creatorcontrib>Huang, Rong</creatorcontrib><creatorcontrib>Gao, Meng</creatorcontrib><creatorcontrib>Liu, Fengxia</creatorcontrib><creatorcontrib>Gui, Rong</creatorcontrib><creatorcontrib>Nie, Xinmin</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cell death discovery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Yanwei</au><au>Fu, Yunfeng</au><au>Huang, Rong</au><au>Gao, Meng</au><au>Liu, Fengxia</au><au>Gui, Rong</au><au>Nie, Xinmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression</atitle><jtitle>Cell death discovery</jtitle><stitle>Cell Death Discov</stitle><addtitle>Cell Death Discov</addtitle><date>2019-07-29</date><risdate>2019</risdate><volume>5</volume><issue>1</issue><spage>121</spage><epage>9</epage><pages>121-9</pages><artnum>121</artnum><issn>2058-7716</issn><eissn>2058-7716</eissn><abstract>Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and a leading cause of cancer-related deaths worldwide. Emerging studies have shown that circular RNAs (circRNAs) are differentially expressed in HCC and play an important role in HCC pathogenesis and metastasis. However, the mechanism of circRNA in the chemoresistance of HCC remains unclear. In this study, we aimed to investigate the role of circRNA in cisplatin resistance of HCC. We identified a novel circRNA circRNA_101505 that was decreased in cisplatin-resistant HCC tissues and cell lines, and associated with a poor survival outcome. Gain-of-function investigations showed that overexpression of circRNA_101505 suppressed cancer cell growth in vivo and in vitro, and enhanced cisplatin toxicity in HCC cells. Mechanistic studies found that circRNA_101505 could sensitize HCC cells to cisplatin by sponging miR-103, and thereby promoting oxidored-nitro domain-containing protein 1 (NOR1) expression. In conclusion, the significant inhibitory effects indicate circRNA_101505 to be a potential therapeutic target for HCC treatment. Our findings provide significant evidence to further elucidate the therapeutic use of circRNA in HCC.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31372241</pmid><doi>10.1038/s41420-019-0202-6</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2058-7716 |
| ispartof | Cell death discovery, 2019-07, Vol.5 (1), p.121-9, Article 121 |
| issn | 2058-7716 2058-7716 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6662675 |
| source | Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access; Springer Nature OA Free Journals |
| subjects | 631/67/1059 692/699/67/1244 Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Chemoresistance Chemotherapy Cisplatin Hepatocellular carcinoma Life Sciences Liver cancer Metastases Stem Cells Therapeutic applications Toxicity Tumors |
| title | CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T18%3A04%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=CircRNA_101505%20sensitizes%20hepatocellular%20carcinoma%20cells%20to%20cisplatin%20by%20sponging%20miR-103%20and%20promotes%20oxidored-nitro%20domain-containing%20protein%201%20expression&rft.jtitle=Cell%20death%20discovery&rft.au=Luo,%20Yanwei&rft.date=2019-07-29&rft.volume=5&rft.issue=1&rft.spage=121&rft.epage=9&rft.pages=121-9&rft.artnum=121&rft.issn=2058-7716&rft.eissn=2058-7716&rft_id=info:doi/10.1038/s41420-019-0202-6&rft_dat=%3Cproquest_pubme%3E2266312293%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2266312293&rft_id=info:pmid/31372241&rfr_iscdi=true |