Control of Lineage-Specific Gene Expression by Functionalized gRNA Barcodes

Lineage tracking delivers essential quantitative insight into dynamic, probabilistic cellular processes, such as somatic tumor evolution and differentiation. Methods for high diversity lineage quantitation rely on sequencing a population of DNA barcodes. However, manipulation of specific individual...

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Veröffentlicht in:	ACS synthetic biology 2018-10, Vol.7 (10), p.2468-2474
Hauptverfasser:	Al’Khafaji, Aziz M, Deatherage, Daniel, Brock, Amy
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Cell Line, Tumor Cell Lineage CRISPR-Associated Protein 9 - genetics Gene Expression HEK293 Cells Humans Lentivirus - physiology
Online-Zugang:	Volltext
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