Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood

Severe obesity is a rapidly growing global health threat. Although often attributed to unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and highly polygenic; the majority of inherited susceptibility is related to the cumulative effect of many common DNA variants...

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Veröffentlicht in:	Cell 2019-04, Vol.177 (3), p.587-596.e9
Hauptverfasser:	Khera, Amit V., Chaffin, Mark, Wade, Kaitlin H., Zahid, Sohail, Brancale, Joseph, Xia, Rui, Distefano, Marina, Senol-Cosar, Ozlem, Haas, Mary E., Bick, Alexander, Aragam, Krishna G., Lander, Eric S., Smith, George Davey, Mason-Suares, Heather, Fornage, Myriam, Lebo, Matthew, Timpson, Nicholas J., Kaplan, Lee M., Kathiresan, Sekar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent adulthood birth weight Body Mass Index Body Weight Child childhood Databases, Factual DNA environmental factors Female genetic risk prediction Genome-Wide Association Study genomic medicine human genetics Humans Infant, Newborn inheritance (genetics) lifestyle Longitudinal Studies Male melanocortin 4 receptor Middle Aged middle-aged adults Multifactorial Inheritance - genetics obesity Obesity - genetics Obesity - pathology polygenic score prediction risk Risk Factors severe obesity Severity of Illness Index UK Biobank weight
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